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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.7 No.2
- 발행연도
- 2015.1
- 수록면
- 199 - 201 (3page)
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초록· 키워드
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Temozolomide is an oral alkylating agent indicated for the treatment of patients with glioblastoma multiforme concomitantly with radiotherapy andsubsequently as monotherapy treatment. We report the case of a patient who developed toxic epidermal necrolysis (TEN) while she was beingtreated with chemoradiotherapy and several drugs. Cutaneous tests were performed with the drugs involved with negative result. Although the occurrenceof TEN contraindicates suspected drug readministration, we based the decision to perform the controlled administration of temozolomideon the following reasons: (1) the poor prognosis of the underlying disease, (2) the lack of therapeutic alternatives, (3) the suspicion that other drugstaken by the patient simultaneously may be responsible (as anticonvulsants and trimethoprim sulfamethoxazole [TMP-SMX]), and (4) temozolomidewas the first choice for treating the patient’s disease. The administration of a cumulative dose of 60 mg of temozolomide caused a slight skin reaction.
Given this result, we conducted controlled administration of other drugs involved. Dexamethasone, codeine, omeprazole and levetiracetamwere well tolerated. However, TMP-SMX produced a similar reaction to that caused by temozolomide. In conclusion, we present the first case ofTEN induced by temozolomide and TMP-SMX associated with cranial radiotherapy confirmed by controlled administration. Radiotherapy in combinationwith these drugs could have favored TEN, as some authors have postulated, but we cannot prove this.
목차
등록된 정보가 없습니다.
참고문헌 (8)
참고문헌 신청
European Medicines Agency (GB). / Annex I: summary of product characteristics
Schwartz RA / 2013 / Toxic epidermal necrolysis:Part I. Introduction, history, classification, clinical features, systemic manifestations, etiology, and immunopathogenesis / J Am Acad Dermatol 69:173
Schwartz RA / 2013 / Toxic epidermal necrolysis:Part II. Prognosis, sequelae, diagnosis, differential diagnosis, prevention, and treatment / J Am Acad Dermatol 69:187
Mónica RG / 2011 / Successful desensitization with temozolomide / Ann Allergy Asthma Immunol 106:541~542
Alonso-Llamazares A / 2012 / Rapid desensitization with temozolomide in patients with delayed maculopapular rash / J Investig Allergol Clin Immunol 22:448~449
Schwartz RA / 2013 / Toxic epidermal necrolysis:Part I. Introduction, history, classification, clinical features, systemic manifestations, etiology, and immunopathogenesis / J Am Acad Dermatol 69:173
Schwartz RA / 2013 / Toxic epidermal necrolysis:Part II. Prognosis, sequelae, diagnosis, differential diagnosis, prevention, and treatment / J Am Acad Dermatol 69:187
Mónica RG / 2011 / Successful desensitization with temozolomide / Ann Allergy Asthma Immunol 106:541~542
Alonso-Llamazares A / 2012 / Rapid desensitization with temozolomide in patients with delayed maculopapular rash / J Investig Allergol Clin Immunol 22:448~449
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