Successful rapid desensitization to trimethoprim-sulfamethoxazole-induced delayed hypersensitivity

윤도란; 안홍근; 김세용; 황성준; 박한기; Hye-Ryun Kang

Successful rapid desensitization to trimethoprim-sulfamethoxazole-induced delayed hypersensitivity

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Trimethoprim-sulfamethoxazole에 대해 지연성 과민반응을 보인 환자에서 성공적인 급속 탈감작 치료 사례 1예

Type: Academic journal

Author: 윤도란 안홍근 김세용 황성준 박한기 Hye-Ryun Kang

Journal: 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제3권 제2호 KCI Accredited Journals

Published: 2015.1

Pages: 155 - 158 (4page)

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Successful rapid desensitization to trimethoprim-sulfamethoxazole-induced delayed hypersensitivity

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Trimethoprim-sulfamethoxazole (TMP-SMX) is an antibiotic used for the treatment or prophylaxis of Pneumocystis pneumonia and other infectious conditions. Sulfonamide derivatives have been reported to cause delayed hypersensitivity reactions, resulting in switch to less effective second-line antibiotics. Although desensitization is traditionally known to be effective in patients with immediate hypersensitivity, it is also applied to the treatment of delayed hypersensitivity in recent years. A 66-year-old female who had a history of repeated TMP-SMX-induced delayed hypersensitivity presenting as whole body rashes needed to take prophylactic dose of TMP-SMX (80/400 mg daily) before initiation of chemotherapy for multiple myeloma. Intravenous rapid desensitization was performed by using a 11-step, 4-bottle protocol from 1:1,000 to 1:1 solution for 3 hours to reach the target dose for prophylaxis. After successful rapid desensitization of TMP-SMX, 1-month prophylaxis was completed without any complications until the patient recovered normal immunity. We herein reported a case of delayed hypersensitivity reaction to TMP-SMX in an about-to-be immunocompromised host with planned chemotherapy who successfully completed 1-month prophylaxis with the drug without any complications through rapid desensitization.

#Sulfamethoxazole #Trimethoprim #Delayed hypersensitivity #Immunologic desensitization

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References (11)

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Bang J / 2008 / Guidance of antibiotic therapy / MIP

Castells M / 2012 / Hypersensitivity to antineoplastic agents : mechanisms and treatment with rapid desensitization / Cancer Immunol Immunother 61 : 1575 ~ 1584

Douglas R / 1997 / Successful desensitization of two patients who previously developed Stevens-Johnson syndrome while receiving trimethoprim-sulfamethoxazole / Clin Infect Di

Millikan LE / 1986 / Immunology of adverse drug eruptions / Clin Dermatol 4 : 30 ~ 39

Patriarca G / 2008 / Desensitization to co-trimoxazole in a patient with fixed drug eruption / J Investig Allergol Clin Immunol 18 : 309 ~ 311

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