Clinicopathological Significance of Dual-Specificity Protein Phosphatase 4 Expression in Invasive Ductal Carcinoma of the Breast

Hyunsung Kim; Se Min Jang; Hyein Ahn; Jongmin Sim; Ki-jong Yi; Yu-min Chung; Hulin Han; Abdul Rehman; 정민성; 장기석; 백승삼

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저자정보: Hyunsung Kim Se Min Jang Hyein Ahn Jongmin Sim Ki-jong Yi Yu-min Chung Hulin Han Abdul Rehman 정민성 장기석 백승삼

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.18 No.1

발행연도: 2015.1

수록면: 1 - 7 (7page)

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Purpose: Dual-specificity protein phosphatase 4 (DUSP4), alsoknown as mitogen-activated protein kinase phosphatase (MKP) 2is a member of the inducible nuclear MKP group. The role ofDUSP4 in cancer development and progression appears to varywith the type of malignancy. The purpose of this study was to investigateDUSP4 expression in a case series of invasive ductalcarcinoma of the breast. Methods: We constructed tissue microarraysconsisting of 16, 14, 47, and 266 cases of normal breast tissue,usual ductal hyperplasia, ductal carcinoma in situ, and invasiveductal carcinoma, respectively. DUSP4 expression was investigatedby immunohistochemistry. Results: Cytoplasmic DUSP4expression was observed. DUSP4 was more frequently expressedin malignant than in benign cases (p=0.024). The mean DUSP4expression score was significantly higher in malignant tumors thanin benign lesions (p=0.019). DUSP4 expression was significantlycorrelated with a larger tumor size (>2 cm, p=0.015). There wasno significant correlation between overall survival or disease-freesurvival and DUSP4 expression in all 266 patients. We evaluatedthe impact of DUSP4 expression on the survival of 120 patientswith T1-stage tumors. Interestingly, Kaplan-Meier survival curvesrevealed that DUSP4 expression had a significant effect on bothoverall patient survival (p=0.034, log-rank test) and disease-freesurvival (p=0.045, log-rank test). In early T-stage breast cancer,DUSP4 expression was associated with a worse prognosis. Conclusion:DUSP4 is frequently upregulated in breast malignancy,and may play an important role in cancer development and progression. In addition, it may be a marker of adverse prognosis, especiallyin patients with early T1-stage cancer.

#Breast neoplasms #Dual-specificity phosphatase 4 #Prognosis

참고문헌 (18)

참고문헌 신청

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