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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 347 - 355 (9page)
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Purpose: CD133 and aldehyde dehydrogenase 1 (ALDH1) expression are reliable poor-prognosis markers associated with the presence of adverse biomarkers and subtypes of breast cancer. The aim of our study was to investigate and compare the clinical impact of CD133 and ALDH1 expression in invasive breast cancer. Methods: A total of 291 consecutive patients with invasive breast cancer who underwent breast cancer operations from 2005 to 2010 at a single institution were included in this retrospective review. CD133 and ALDH1 expression were determined by immunohistochemistry. Results: CD133 and ALDH1 expression were positive in 24.7% and 22.0% of the patients, respectively, and were associated with tumor size, cancer stage, estrogen receptor negativity, nonluminal subtype, triple-negative breast cancer, and recurrence. CD133 expression was significantly associated with lymph node metastasis, progesterone receptor negativity, human epidermal growth factor receptor 2 positivity, chemotherapy, and poor disease-free (p=0.002) and overall survival (p=0.014), but ALDH1 expression was not. Cancer stage (p<0.001) was an independent prognostic factor for disease-free survival in multivariate analysis. Cancer stage (p<0.001) and receipt of radiotherapy (p=0.045) were independent prognostic factors for overall survival in multivariate analysis. Conclusion: CD133 or the combination of CD133 and ALDH1 expression were more widely associated with the presence of adverse biomarkers and subtypes of breast cancer, compared to ALDH1 expression alone, and these markers may have a potential predictive role and be a helpful tool in the management for patients with invasive breast cancer.
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참고문헌 (20)
참고문헌 신청
Resetkova E / 2010 / Prognostic impact of ALDH1 in breast cancer : a story of stem cells and tumor microenvironment / Breast Cancer Res Treat 123:97~108
Tsang JY / 2012 / Cancer stem cell markers are associated with adverse biomarker profiles and molecular subtypes of breast cancer / Breast Cancer Res Treat 136:407~417
Ginestier C / 2007 / ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome / Cell Stem Cell 1:555~567
Croker AK / 2008 / Cancer stem cells : implications for the progression and treatment of metastatic disease / J Cell Mol Med 12:374~390
Chuthapisith S / 2010 / Breast cancer chemoresistance : emerging importance of cancer stem cells / Surg Oncol 19:27~32
Tsang JY / 2012 / Cancer stem cell markers are associated with adverse biomarker profiles and molecular subtypes of breast cancer / Breast Cancer Res Treat 136:407~417
Ginestier C / 2007 / ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome / Cell Stem Cell 1:555~567
Croker AK / 2008 / Cancer stem cells : implications for the progression and treatment of metastatic disease / J Cell Mol Med 12:374~390
Chuthapisith S / 2010 / Breast cancer chemoresistance : emerging importance of cancer stem cells / Surg Oncol 19:27~32
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