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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.5 No.3
- 발행연도
- 2015.1
- 수록면
- 188 - 193 (6page)
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Purpose Migration of T cells is critical for immune surveillanceand immune responses. Microtubule is the largest cytoskeletonand it is highly related with cell migration, but the role ofmicrotubule on T cell migration under confined environments,which is an emergent property of interstitial spaces in vivofor leukocyte migration, has not been studied. Methods In this study, we first fabricated two different typesof microchannels, wide microchannels (WMCs) that onlyconfines T cells in vertical direction, and narrow microchannels(NMCs) that confines T cells in both vertical and horizontaldirections. Then, morphology, velocity, and directionalpersistence of T cells in the different confined conditionswere quantitatively analyzed. In addition, pharmacologicalinhibitors modulating microtubule stability were used toassess the roles of microtubule dynamics on T cell migrationunder confinement. Results T cells within microchannels were tightly confined,exhibiting flattened or elongated morphologies depending onwhether they were in WMCs or NMCs. Velocity and directionalpersistent of T cells increased as the degree of confinementincreased. In addition, Taxol-treatment significantly reduceddirectional persistence of T cells under confined environments. Conclusions Dynamics of microtubule played an importantrole in the directional persistency of T cells in confinedenvironments.
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참고문헌 (29)
참고문헌 신청
Von Andrian UH / 2000 / T-cell function and migration:Two sides of the same coin / New Engl J Med 343:1020~1034
Bromley SK / 2008 / Orchestrating the orchestrators: chemokines in control of T cell traffic / Nat Immunol 9:970~980
Miller MJ / 2002 / Two-photon imaging of lymphocyte motility and antigen response in intact lymph node / Science 296:1869~1873
Miller MJ / 2003 / Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy / Proc Natl Acad Sci USA 100:2604~2609
Friedl P / 2008 / Interstitial leukocyte migration and immune function / Nat Immunol 9:960~969
Bromley SK / 2008 / Orchestrating the orchestrators: chemokines in control of T cell traffic / Nat Immunol 9:970~980
Miller MJ / 2002 / Two-photon imaging of lymphocyte motility and antigen response in intact lymph node / Science 296:1869~1873
Miller MJ / 2003 / Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy / Proc Natl Acad Sci USA 100:2604~2609
Friedl P / 2008 / Interstitial leukocyte migration and immune function / Nat Immunol 9:960~969
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