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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 81 - 91 (11page)
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In the last two decades, numerous researchers have focused on elucidating the relationship between the skeletal and immune systems with respect to their regulatory mechanisms. It has now become clear that osteoclasts are derived fromthe same myeloid precursor cells that can differentiate into macrophages and myeloid dendritic cells. In addition, bone and immune cells coexist in the common microenvironment of the bone marrow and are thus influenced by similar mediators. Discovery of a common regulatory mechanism via the receptor activator of nuclear factor kappa-B ligand (RANKL)ereceptor activator of NF-kB (RANK)eosteoprotegerin (OPG) axis in both the bone and immune system has not only increased understanding of the fundamental processes of bone homeostasis but has further crystalized understanding of the definitive regulatory correlation between bone and immunity. Moreover, many of the soluble mediators produced by immune cells, including cytokines, chemokines, and growth factors, regulate the activities of osteoclasts and osteoblasts. This increased recognition of the complex interactions between the immune system and bone has led to the development of the interdisciplinary field of osteoimmunology. In this review, we summarize the characteristics of bone cells and the soluble mediators responsible for crosstalk between the skeletal and immune systems. A more complete appreciation of the interactions between immune and bone cells should lead to better therapeutic strategies for diseases that affect either or both systems. ©2015 The Korean Society of Osteoporosis. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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참고문헌 (100)
참고문헌 신청
Walsh MC / 2006 / Osteoimmunology: interplay between the immune system and bone metabolism / Annu Rev Immunol 24:33~63
Lorenzo J / 2008 / Osteoimmunology: interactions of the bone and immune system / Endocr Rev 29:403~440
Wong BR / 1997 / TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor / J Exp Med 186:2075~2080
Yasuda H / 1998 / Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL / Proc Natl Acad Sci 95:3597~3602
Lacey DL / 1998 / Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation / Cell 93:165~176
Lorenzo J / 2008 / Osteoimmunology: interactions of the bone and immune system / Endocr Rev 29:403~440
Wong BR / 1997 / TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor / J Exp Med 186:2075~2080
Yasuda H / 1998 / Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL / Proc Natl Acad Sci 95:3597~3602
Lacey DL / 1998 / Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation / Cell 93:165~176
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