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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 249 - 260 (12page)
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In this study, we investigated whether the single nucleotide polymorphisms (SNPs) associated with telomere length (TL) were associated with the incidence of hypertension (HTN)/coronary heart disease (CHD) and cardiovascular risk factors in the Korean population. Data from 5,705 (ages 39–70) participants in the Korean Genome Epidemiology Study (rural Ansung and urban Ansan cohorts) were studied. Twelve SNPs known to be associated with telomere biology were tested for an association with HTN/CHD. As results, no significant associations were found between the selected TL-related SNPs and prevalence of HTN and CHD. Among non-alcohol users, subjects with minor alleles in rs1269304 and rs10936601 (TERC and LRRC34, respectively) exhibited a higher rate of CHD occurrence (odds ratio [OR], 1.862; 95% confidence intervals [CIs], 1.137, 3.049; OR, 1.855; 95% CIs, 1.111, 2.985; respectively). However, alcohol users with minor alleles in rs398652 (PELI2) were significantly associated with higher HTN prevalence (OR, 1.179; 95% CIs, 1.040, 1.336). Of the 3 SNPs related to disease outcomes, rs1296304 was significantly associated with increased levels of diastolic blood pressure (β estimate, 0.470; 95% CIs, 0.013, 0.926). The minor allele in rs398652 was significantly associated with higher levels of body mass index (OR, 0.128; 95% CIs, 0.010, 0.246) and γ-glutamyl transpeptidase (OR, 0.013; 95% CIs, 0.001, 0.024). In conclusion, there were no significant associations between the selected TL-related SNPs and the occurrence of HTN/CHD in Koreans. However, the results suggest the presence of a possible interaction between related SNPs and alcohol behavior associated with HTN/CHD occurrence.
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참고문헌 (34)
참고문헌 신청
Codd V / 2010 / Common variants near TERC are associated with mean telomere length / Nat Genet 42:197~199
de Lange T / 2002 / Protection of mammalian telomeres / Oncogene 21:532~540
de Lange T / 2005 / Shelterin: the protein complex that shapes and safeguards human telomeres / Genes Dev 19:2100~2110
Portugal RD / 2008 / A computational model for telomere-dependent cell-replicative aging / Biosystems 91:262~267
Samani NJ / 2001 / Telomere shortening in atherosclerosis / Lancet 358:472~473
de Lange T / 2002 / Protection of mammalian telomeres / Oncogene 21:532~540
de Lange T / 2005 / Shelterin: the protein complex that shapes and safeguards human telomeres / Genes Dev 19:2100~2110
Portugal RD / 2008 / A computational model for telomere-dependent cell-replicative aging / Biosystems 91:262~267
Samani NJ / 2001 / Telomere shortening in atherosclerosis / Lancet 358:472~473
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