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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 26 - 32 (7page)
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To evaluate the effect of diet on metabolic control and zinc metabolism in patients with type 2 diabetes mellitus (T2DM). One-week balanced diet was provided to 10 Brazilians patients with T2DM. Nutritional assessment, laboratorial parameters and expression of zinc transporter and inflammatory genes in peripheral blood mononuclear cells (PBMC) were performed. Healthy non-diabetic subjects of the same demographic were recruited to provide baseline data. Diabetic patients had higher body mass index and greater fasting plasma glucose, plasma tumor necrosis factor α (TNFα) and plasma interleukin 6 (IL6) levels compared with healthy subjects. In addition, the expression of transporters 4 (ZnT4) mRNA was lower and IL6 mRNA was higher in PBMC of these diabetic patients than in healthy subject. One week after a balanced diet was provided, fasting plasma glucose decreased significantly as did TNFα, IL6 and Metallothionein 1 (MT1) mRNAs. No change was observed in zinc transporter expression in PBMC after the dietary intervention. A healthy eating pattern maintained for one week was able to improve metabolic control of diabetic patients by lowering fasting plasma glucose. This metabolic control may be related to down-regulation of zinc-related transcripts from PBMCs, as TNFα, IL6 and MT1 mRNA.
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참고문헌 (29)
참고문헌 신청
Jansen J / 2012 / Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc / J Nutr Biochem 23:1458~1466
Miao X / 2013 / Zinc homeostasis in the metabolic syndrome and diabetes / Front Med 7:31~52
Capdor J / 2013 / Zinc and glycemic control : a meta-analysis of randomised placebo controlled supplementation trials in humans / J Trace Elem Med Biol 27:137~142
Chimienti F / 2013 / Zinc, pancreatic islet cell function and diabetes: new insights into an old story / Nutr Res Rev 26:1~11
Ryu MS / 2011 / Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis / Proc Natl Acad Sci U S A 108:20970~20975
Miao X / 2013 / Zinc homeostasis in the metabolic syndrome and diabetes / Front Med 7:31~52
Capdor J / 2013 / Zinc and glycemic control : a meta-analysis of randomised placebo controlled supplementation trials in humans / J Trace Elem Med Biol 27:137~142
Chimienti F / 2013 / Zinc, pancreatic islet cell function and diabetes: new insights into an old story / Nutr Res Rev 26:1~11
Ryu MS / 2011 / Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis / Proc Natl Acad Sci U S A 108:20970~20975
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