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논문 기본 정보

자료유형
학술저널
저자정보
Marijo Parcina (University of Heidelberg) Maik Brune (University of Heidelberg) Vareska Kaese (University of Heidelberg) Markus Zorn (University of Heidelberg) Rainer Spiegel (University of Heidelberg) Valerija Vojvoda (Institute of Immunology) Thomas Fleming (University of Heidelberg) Gottfried Rudofsky (University of Heidelberg) Peter Paul Nawroth (University of Heidelberg)
저널정보
한국영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.9 No.2
발행연도
2015.4
수록면
165 - 173 (9page)

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초록· 키워드

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BACKGROUND/OBJECTIVES: This study addressed the question whether the composition of supposedly ‘healthy’ or ‘unhealthy’ dietary regimes has a calorie-independent short-term effect on biomarkers of metabolic stress and vascular risk in healthy individuals.
SUBJECTS/METHODS: Healthy male volunteers (age 29.5 ± 5.9 years, n = 39) were given a standardized baseline diet for two weeks before randomization into three groups of different dietary regimes: fast food, Mediterranean and German cooking style. Importantly, the amount of calories consumed per day was identical in all three groups. Blood samples were analyzed for biomarkers of cardiovascular risk and metabolic stress after two weeks of the baseline diet and after two weeks of the assigned dietary regime.
RESULTS: No dietary intervention affected the metabolic or cardiovascular risk profile when compared in-between groups or compared to baseline. Subjects applied to the Mediterranean diet showed a statistically significant increase of uric acid compared to baseline and compared to the German diet group. Plasma concentrations of urea were significantly higher in both the fast food group and the Mediterranean group, when compared to baseline and compared to the German diet group. No significant differences were detected for the levels of vitamins, trace elements or metabolic stress markers (8-hydroxy-2-deoxyguanosine, malondialdehyde and methylglyoxal, a potent glycating agent). Established parameters of vascular risk (e.g. LDL-cholesterol, lipoprotein(a), homocysteine) were not significantly changed in-between groups or compared to baseline during the intervention period.
CONCLUSIONS: The calorie-controlled dietary intervention caused neither protective nor harmful short-term effects regarding established biomarkers of vascular or metabolic risk. When avoiding the noxious effects of overfeeding, healthy individuals can possess the metabolic capacity to compensate for a potentially disadvantageous composition of a certain diet.

목차

INTRODUCTION
SUBJECTS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2016-594-001319011