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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 7 - 14 (8page)
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Folate, vitamin B12, and homocysteine (HCY) are involved in the metabolism of nucleic acid precursors and it has been hypothesized that they also influence telomere length, a biomarker of aging. However, previous studies have reported inconsistent findings, and data for older adults are limited. Our study aimed to evaluate associations between leukocyte telomere length (LTL) and serum folate, vitamin B12, and HCY levels among adults aged 55 years and over. In a cross-sectional study in 798 men and women aged 55-79 years, serum folate, vitamin B12, and HCY levels were measured using chemiluminescent immunometric assays, and relative LTL was assessed using quantitative real-time polymerase chain reaction. To evaluate associations between LTL and serum folate, vitamin B12, and HCY levels, multiple linear regression models were used. In multiple models adjusted for age, sex, serum high sensitive C-reactive protein (hs-CRP) levels, and other potential confounding factors, we found no association between LTL and serum folate, vitamin B12, and HCY levels. However, we did find a significant inverse association between HCY levels and LTL in participants with serum hs-CRP levels of ≥ 2 mg/L (p < 0.05). Moreover, there was a trend toward an association between HCY and vitamin B12 levels in these individuals (p = 0.08). In those with serum hs-CRP levels of < 2 mg/L, HCY was inversely associated with vitamin B12 levels (p < 0.001) and had no association with LTL. Our findings suggest that increased serum HCY levels, when combined with the presence of systemic inflammation, may play a role in accelerating biological aging.
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참고문헌 (30)
참고문헌 신청
Mason JB / 2003 / Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism / J Nutr 133(Suppl 3):941S~947S
Arinze IJ / 2005 / Facilitating understanding of the purine nucleotide cycle and the one-carbon pool : Part I : The purine nucleotide cycle / Biochem Mol Biol Educ 33:165~168
Fenech M / 2012 / Folate(vitamin B9)and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity / Mutat Res 733:21~33
Crider KS / 2012 / Folate and DNA methylation : a review of molecular mechanisms and the evidence for folate's role / Adv Nutr 3:21~38
Paul L / 2009 / Telomere length in peripheral blood mononuclear cells is associated with folate status in men / J Nutr 139:1273~1278
Arinze IJ / 2005 / Facilitating understanding of the purine nucleotide cycle and the one-carbon pool : Part I : The purine nucleotide cycle / Biochem Mol Biol Educ 33:165~168
Fenech M / 2012 / Folate(vitamin B9)and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity / Mutat Res 733:21~33
Crider KS / 2012 / Folate and DNA methylation : a review of molecular mechanisms and the evidence for folate's role / Adv Nutr 3:21~38
Paul L / 2009 / Telomere length in peripheral blood mononuclear cells is associated with folate status in men / J Nutr 139:1273~1278
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