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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 질병관리본부 Osong Public Health and Research Persptectives Osong Public Health and Research Persptectives Vol.8 No.5
- 발행연도
- 2017.1
- 수록면
- 325 - 331 (7page)
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Objectives: Studies on Clostridium difficile are rare in Korea. We investigated the epidemiological characteristics of C. difficile isolates from patients with C. difficile-associated disease (CDAD) in Korea. Methods: Multiplex polymerase chain reaction was performed to detect the presence of tcdA and tcdB toxin genes. Antimicrobial susceptibility test was carried out by the disk-dilution method. C. difficile strains were subtyped by automated repetitive-element palindromic PCR (rep-PCR). Results: Among patients with CDAD, 73 (25.8%), 32 (11.3%), 32 (11.3%), and 26 (9.2%) suffered from pneumonia, cancer or neoplasm, diabetes, and colitis, respectively. Of all stool samples, 43 samples (15.2%) were positive for C. difficile strains. We observed two expression patterns of toxin genes: tcdA+/tcdB+ (86% isolates) and tcdA−/tcdB+ (14% isolates), with all isolates expressing tcdB. Furthermore, some isolates were resistant to clindamycin (65%), ampicillin (56%), and cefazolin (40%), but all were susceptible to vancomycin and metronidazole. The tested samples were classified into diverse clusters using automated rep-PCR. Conclusion: Our findings revealed the characteristics and antibiotic resistance of C. difficile isolates from patients in Korea. The epidemiological data may provide valuable insight into development of treatment strategies for C. difficile infections in Korea.
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참고문헌 (18)
참고문헌 신청
Maja Rupnik / 2009 / Clostridium difficile infection: new developments in epidemiology and pathogenesis / Nature Reviews Microbiology 7(7):526~536
M. Delmee / 2005 / Laboratory diagnosis of Clostridium difficile-associated diarrhoea: a plea for culture / Journal of Medical Microbiology 54(2):187~191
Stuart H. Cohen / 2010 / Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA) / Infection Control and Hospital Epidemiology 31(5):431~455
조혜정 / 2010 / 소아에서 발생한 Clostridium difficile 관련 질환의 역학과 임상양상: 지역사회감염과 원내감염의 비교 / Pediatric Gastroenterology, Hepatology & Nutrition 13(2):146~153
변태준 / 2009 / Clostridium difficile-Associated Disease (CDAD)의 최근 임상양상의 변화 / 대한소화기학회지 54(1):13~19
M. Delmee / 2005 / Laboratory diagnosis of Clostridium difficile-associated diarrhoea: a plea for culture / Journal of Medical Microbiology 54(2):187~191
Stuart H. Cohen / 2010 / Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA) / Infection Control and Hospital Epidemiology 31(5):431~455
조혜정 / 2010 / 소아에서 발생한 Clostridium difficile 관련 질환의 역학과 임상양상: 지역사회감염과 원내감염의 비교 / Pediatric Gastroenterology, Hepatology & Nutrition 13(2):146~153
변태준 / 2009 / Clostridium difficile-Associated Disease (CDAD)의 최근 임상양상의 변화 / 대한소화기학회지 54(1):13~19
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