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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아혈액종양학회 Clinical Pediatric Hematology-Oncology Clinical Pediatric Hematology-Oncology Vol.24 No.2
- 발행연도
- 2017.1
- 수록면
- 153 - 156 (4page)
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We describe our experience regarding metronidazole-induced encephalopathy in a patient with acute lymphoblastic leukemia during chemotherapy. A 17-year-old girl was admitted to our institution with complaints of abdominal pain and mucoid stools. She was diagnosed with acute lymphoblastic leukemia and had been undergoing intensified chemotherapy protocol. During the fifth week of interim maintenance-1 therapy, she developed a fever and complained of chills. On stool examination, stool occult blood was positive and Clostridium difficile toxin A/B test was positive. She was started on metronidazole treatment for possible Clostridium difficile infection and other inflammatory gastrointestinal diseases. Ten days later, the patient complained of dizziness and nausea. A brain MRI was performed to make a differential diagnosis of any chemotherapy-induced CNS complication such as necrotizing leukoencephalopathy. The brain MRI showed features of metronidazole-induced encephalopathy. Metronidazole was discontinued and symptoms started to subside four days after. A follow-up brain MRI performed at four weeks showed that lesions of the dentate nucleus had disappeared.
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참고문헌 (10)
참고문헌 신청
Minisini AM / 2008 / Anticancer drugs and central nervous system: clinical issues for patients and physicians / Cancer Lett 267:1~9
Kim KI / 2007 / A case of reversible posterior leukoencephalopathy in a child with acute lymphoblastic leukemia / Clin Pediatr Hematol Oncol 14:78~82
Rolston KV / 2009 / New antimicrobial agents for the treatment of bacterial infections in cancer patients / Hematol Oncol 27:107~114
Kuriyama A / 2011 / Metronidazole-induced central nervous system toxicity: a systematic review / Clin Neuropharmacol 34:241~247
Mattano LA Jr / 2012 / Effects of dexamethasone (DEX) vs prednisone (PDN) and high-dose methotrexate (HD-MTX) vs capizzi methotrexate/asparaginase (C-MTX/ASNase) on osteonecrosis (ON) incidence in children and young adults with high risk acute lymphoblastic leukemia (HR-ALL): A report from the Children's Oncology Group (COG) Study AALL0232 / Blood 120:665
Kim KI / 2007 / A case of reversible posterior leukoencephalopathy in a child with acute lymphoblastic leukemia / Clin Pediatr Hematol Oncol 14:78~82
Rolston KV / 2009 / New antimicrobial agents for the treatment of bacterial infections in cancer patients / Hematol Oncol 27:107~114
Kuriyama A / 2011 / Metronidazole-induced central nervous system toxicity: a systematic review / Clin Neuropharmacol 34:241~247
Mattano LA Jr / 2012 / Effects of dexamethasone (DEX) vs prednisone (PDN) and high-dose methotrexate (HD-MTX) vs capizzi methotrexate/asparaginase (C-MTX/ASNase) on osteonecrosis (ON) incidence in children and young adults with high risk acute lymphoblastic leukemia (HR-ALL): A report from the Children's Oncology Group (COG) Study AALL0232 / Blood 120:665
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