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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아혈액종양학회 Clinical Pediatric Hematology-Oncology Clinical Pediatric Hematology-Oncology Vol.24 No.2
- 발행연도
- 2017.1
- 수록면
- 130 - 135 (6page)
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초록· 키워드
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Background: We compared the yields of mobilized PBSCs from single day of normal volume leukapheresis (NVL) in children and adults, and factors affecting the yields, to understand differences in mobilization efficiency between adults and small children with healthy marrows. Methods: This study involved 18 adult volunteer donors and 47 small children weighing less than 20 kg who participated in a clinical trial of cell therapy in children with cerebral palsy. Donor factors analyzed to identify predictors of the yield of apheresis included age, gender, weight and complete blood cell count (CBC) with differential counts as well as equipment parameters. Results: The yields of total nucleated cells (TNCs) and CD34＋cells in the apheresis products of the children were significantly lower than in those from healthy adults. However, the efficiency of recovery of PBSCs (total CD34＋ cell counts/TNCs) was significantly higher in small children (0.48±0.30%) than in adults (0.10±0.05%) (P＜0.05). Multivariable analysis of adult donor factors showed that the processed volume and flow rate of apheresis were significantly associated with the yield of TNCs (P＜0.05, for both), but not of CD34＋cells. However, in multivariable analysis of child donor factors, body weight and circulating WBC count on the day of apheresis were significantly associated with the yield of TNCs (P＜0.05, for both) and of CD34＋cells (P＜0.05, for both). Conclusion: The predictors of PBSC yields from a single day of NVL in adults and small children are different. Also mobilization is more effective in small children than in adults.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Mavroudis D / 1996 / CD34+ cell dose predicts survival, posttransplant morbidity, and rate of hematologic recovery after allogeneic marrow transplants for hematologic malignancies / Blood 88:3223~3229
Pulsipher MA / 2009 / Donor, recipient, and transplant characteristics as risk factors after unrelated donor PBSC transplantation: beneficial effects of higher CD34+ cell dose / Blood 114:2606~2616
Nakamura R / 2008 / Impact of graft cell dose on transplant outcomes following unrelated donor allogeneic peripheral blood stem cell transplantation: higher CD34+ cell doses are associated with decreased relapse rates / Biol Blood Marrow Transplant 14:449~457
Hölig K / 2009 / Safety and efficacy of hematopoietic stem cell collection from mobilized peripheral blood in unrelated volunteers: 12 years of single-center experience in 3928 donors / Blood 114:3757~3763
Stroncek DF / 1999 / Collection of two peripheral blood stem cell concentrates from healthy donors / Transfus Med 9:37~50
Pulsipher MA / 2009 / Donor, recipient, and transplant characteristics as risk factors after unrelated donor PBSC transplantation: beneficial effects of higher CD34+ cell dose / Blood 114:2606~2616
Nakamura R / 2008 / Impact of graft cell dose on transplant outcomes following unrelated donor allogeneic peripheral blood stem cell transplantation: higher CD34+ cell doses are associated with decreased relapse rates / Biol Blood Marrow Transplant 14:449~457
Hölig K / 2009 / Safety and efficacy of hematopoietic stem cell collection from mobilized peripheral blood in unrelated volunteers: 12 years of single-center experience in 3928 donors / Blood 114:3757~3763
Stroncek DF / 1999 / Collection of two peripheral blood stem cell concentrates from healthy donors / Transfus Med 9:37~50
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