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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 631 - 639 (9page)
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초록· 키워드
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Tracheal restenosis is a major obstacle to successful tracheal replacement, and remains the greatest challenge in tracheal regeneration. However, there have been no detailed investigations of restenosis. The present study was performed to analyze the serial changes in recruited inflammatory cells and associated histological changes after tracheal scaffold implantation. Asymmetrically porous scaffolds, which successfully prevented tracheal stenosis in a partial trachea defect model, designed with a tubular shape by electrospinning and reinforced by 3D-printing to reconstruct 2-cm circumferential tracheal defect. Serial rigid bronchoscopy, micro-computed tomography, and histology [H&E, Masson’s Trichrome, IHC against a-smooth muscle actin (a-SMA)] were performed 1, 4, and 8 weeks after transplantation. Progressive stenosis developed especially at the site of anastomosis. Neutrophils were the main inflammatory cells recruited in the early stage, while macrophage infiltration increased with time. Recruitment of fibroblasts peaked at 4 weeks and deposition of a-SMA increased from 4 weeks and was maintained through 8 weeks. During the first 8 weeks post-transplantation, neutrophils and macrophages played significant roles in restenosis of the trachea. Antagonists to these would be ideal targets to reduce restenosis and thus play a pivotal role in successful tracheal regeneration.
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등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Hagberg C / 2005 / Complications of managing the airway / Best Pract Res Clin Anaesthesiol 19:641~659
Wain JC Jr / 2009 / Postintubation tracheal stenosis / Semin Thorac Cardiovasc Surg 21:284~289
Daumerie G / 2010 / Anesthesia for the patient with tracheal stenosis / Anesthesiol Clin 28:157~174
Shapshay SM / 1987 / Endoscopic treatment of subglottic and tracheal stenosis by radial laser incision and dilation / Ann Otol Rhinol Laryngol 96:661~664
Lee KE / 2009 / Management of airway involvement of oesophageal cancer using covered retrievable nitinol stents / Clin Radiol 64:133~141
Wain JC Jr / 2009 / Postintubation tracheal stenosis / Semin Thorac Cardiovasc Surg 21:284~289
Daumerie G / 2010 / Anesthesia for the patient with tracheal stenosis / Anesthesiol Clin 28:157~174
Shapshay SM / 1987 / Endoscopic treatment of subglottic and tracheal stenosis by radial laser incision and dilation / Ann Otol Rhinol Laryngol 96:661~664
Lee KE / 2009 / Management of airway involvement of oesophageal cancer using covered retrievable nitinol stents / Clin Radiol 64:133~141
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