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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 225 - 233 (9page)
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BACKGROUND: Long segmental tracheal repair is challenging in regenerative medicine due to low adhesion of stem cells to tracheal scaffolds. Optimal transplantation of stem cells for tracheal defects has not been established. We evaluated the role of hyaluronic acid (HA) coating of tracheal scaffolds in mesenchymal stem cell (MSC) adhesion and tracheal regeneration in a rabbit model. METHODS: A three-dimensionally printed tubular tracheal prosthesis was incubated with dopa-HA-fluorescein isothiocyanate in phosphate-buffered saline for 2 days. MSCs were incubated with an HA-coated scaffold, and their adhesion was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. HA coated scaffolds with or without MSC seeding were transplanted at the circumferential tracheal defect in rabbits, and survival, rigid bronchoscopy, radiologic findings, and histologic findings were compared between the two groups. RESULTS: HA-coated scaffolds showed better MSC adhesion than non-coated scaffolds. The HA-coated scaffolds with MSC group showed a wider airway and greater mucosal regeneration compared to the HA-coated scaffolds without MSC group. CONCLUSION: HA coating of scaffolds can promote MSC adhesion and tracheal regeneration.
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참고문헌 (43)
참고문헌 신청
안희진 / 2017 / Serial Analysis of Tracheal Restenosis After 3D-Printed Scaff old Implantation: Recruited Infl ammatory Cells and Associated Tissue Changes / 조직공학과 재생의학 14(5):631~639
Du XF / 2012 / Tracheal reconstruction by mesenchymal stem cells with small intestine submucosa in rabbits / Int J Pediatr Otorhinolaryngol 76:345~351
Kim IG / 2020 / Transplantation of a 3D-printed tracheal graft combined with iPS cell-derived MSCs and chondrocytes / Sci Rep 10:4326
Lee DY / 2015 / Synergistic effect of laminin and mesenchymal stem cells on tracheal mucosal regeneration / Biomaterials 44:134~142
Kim SH / 2015 / Hydrogel-laden paper scaffold system for origami-based tissue engineering / Proc Natl Acad Sci U S A 112:15426~15431
Du XF / 2012 / Tracheal reconstruction by mesenchymal stem cells with small intestine submucosa in rabbits / Int J Pediatr Otorhinolaryngol 76:345~351
Kim IG / 2020 / Transplantation of a 3D-printed tracheal graft combined with iPS cell-derived MSCs and chondrocytes / Sci Rep 10:4326
Lee DY / 2015 / Synergistic effect of laminin and mesenchymal stem cells on tracheal mucosal regeneration / Biomaterials 44:134~142
Kim SH / 2015 / Hydrogel-laden paper scaffold system for origami-based tissue engineering / Proc Natl Acad Sci U S A 112:15426~15431
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