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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 284 - 296 (13page)
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초록· 키워드
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The MTT assay showed that the cell proliferation on hydroxyapatite (HAp) and HAp/bone morphogenic protein (BMP) coated group was better than the control and BMP coated groups at 5 days. And after 7 days of culture, the mRNA expression levels of type I collagen, osteonectin, osteopontin, bonesialoprotein, BMP-2, alkaline phosphatase (ALP) and Runx-2 in the HAp/BMP coated group were significantly higher than the other groups. Also, in this group showed the most significant induction of osteogenic gene expression compared to mesenchymal stem cells (MSCs) grown on the other groups. In addition, the cells in the HAp/BMP coated group delivered higher levels of ALP than the other three groups. Also, silk scaffolds were implanted as artificial ligaments in knees of rabbits, and they were harvested 1 and 3 months after implantation. On gross examination, HE staining showed that new bone tissue formation was more observed in the HAp/BMP coated group 3 weeks postoperatively. And masson staining showed that in the HAp/BMP coated group, the silk fibers were encircled by osteoblast, chondrocyte, and collagen. Furthermore, the analysis showed that the width of the graft-bone interface in the HAp and HAp/BMP coated group was narrower than that in the other two groups 3 weeks postoperatively. So, it is concluded that BMP incorporated HAp coated silk scaffold can be enhanced osseointegration and osteogenesis in bone tunnel. As a result, these experimental designs have been demonstrated to be effective in the acceleration of graft-to-bone healing by increasing new bone or fibrocartilage formation at the interface between graft and bone.
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참고문헌 (37)
참고문헌 신청
Weitzel PP / 2002 / Future direction of the treatment of ACL ruptures / Orthop Clin North Am 33:653~661
Cooper JA / 2005 / Fiber-based tissue-engineered scaffold for ligament replacement : design considerations and in vitro evaluation / Biomaterials 26:1523~1532
Freeman JW / 2008 / Recent advancements in ligament tissue engineering: the use of various techniques and materials for ACL repair / Recent Pat Biomed Eng 1:18~23
Murray AW / 2004 / 10-16 year results of Leeds-Keio anterior cruciate ligament reconstruction / Knee 11:9~14
Keen CE / 1999 / Polyester fibre prosthetic anterior cruciate ligament implant rupture: necrosis of ingrown connective tissue / Histopathology 35:74~81
Cooper JA / 2005 / Fiber-based tissue-engineered scaffold for ligament replacement : design considerations and in vitro evaluation / Biomaterials 26:1523~1532
Freeman JW / 2008 / Recent advancements in ligament tissue engineering: the use of various techniques and materials for ACL repair / Recent Pat Biomed Eng 1:18~23
Murray AW / 2004 / 10-16 year results of Leeds-Keio anterior cruciate ligament reconstruction / Knee 11:9~14
Keen CE / 1999 / Polyester fibre prosthetic anterior cruciate ligament implant rupture: necrosis of ingrown connective tissue / Histopathology 35:74~81
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