지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 145 - 150 (6page)
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초록· 키워드
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123I-meta-iodobenzylguanidine (MIBG) has become widely applied in Japan since its introduction to clinical cardiology and neurology practice in the 1990s. Neurological studies found decreased cardiac uptake of 123I-MIBG in Lewy-body diseases including Parkinson’s disease and dementia with Lewy bodies. Thus, cardiac MIBG uptake is now considered a biomarker of Lewy body diseases. Although scintigraphic images of 123I-MIBG can be visually interpreted, an average count ratio of heart-to-mediastinum (H/M) has commonly served as a semi-quantitative marker of sympathetic activity. Since H/M ratios significantly vary according to acquisition and processing conditions, quality control should be appropriate, and quantitation should be standardized. The threshold H/M ratio for differentiating Lewy-body disease is 2.0-2.1, and was based on standardized H/M ratios to comparable values of medium-energy collimators. Parkinson’s disease can be separated from various types of parkinsonian syndromes using cardiac 123I-MIBG, whereas activity is decreased on images of Lewy-body diseases using both 123I-ioflupane for the striatum and 123I-MIBG. Despite being a simple index, the H/M ratio of 123I-MIBG uptake is reproducible and can serve as an effective tool to support a diagnosis of Lewy-body diseases in neurological practice.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Tamaki N / 2005 / Guidelines for clinical use of cardiac nuclear medicine (JCS 2005) / Circ J 69(Suppl IV):1125~1202
Nakajima K / 2015 / Cardiac 123I-MIBG Imaging for Clinical Decision Making: 22-Year Experience in Japan / J Nucl Med 56(Suppl 4):11S~19S
McKeith IG / 2006 / Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop / J Alzheimers Dis 9(3 Suppl):417~423
Nakajima K / 2014 / Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations / J Nucl Cardiol 21:970~978
Slomka PJ / 2014 / Quantification of I-123-meta-iodobenzylguanidine heart-to-mediastinum ratios:not so simple after all / J Nucl Cardiol 21:979~983
Nakajima K / 2015 / Cardiac 123I-MIBG Imaging for Clinical Decision Making: 22-Year Experience in Japan / J Nucl Med 56(Suppl 4):11S~19S
McKeith IG / 2006 / Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop / J Alzheimers Dis 9(3 Suppl):417~423
Nakajima K / 2014 / Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations / J Nucl Cardiol 21:970~978
Slomka PJ / 2014 / Quantification of I-123-meta-iodobenzylguanidine heart-to-mediastinum ratios:not so simple after all / J Nucl Cardiol 21:979~983
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