지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Background: Despite major advances in lung cancer treatment, early detection remains the most promising way of improving outcomes. To detect lung cancer in earlier stages, many serum biomarkers have been tested. Unfortunately, no single biomarker can reliably detect lung cancer. We combined a set of 2 tumor markers and 4 inflammatory or metabolic markers and tried to validate the diagnostic performance in lung cancer. Methods: We collected serum samples from 355 lung cancer patients and 590 control subjects and divided them into training and validation datasets. After measuring serum levels of 6 biomarkers (human epididymis secretory protein 4 [HE4], carcinoembryonic antigen [CEA], regulated on activation, normal T cell expressed and secreted [RANTES], apolipoprotein A2 [ApoA2], transthyretin [TTR], and secretory vascular cell adhesion molecule-1 [sVCAM-1]), we tested various sets of biomarkers for their diagnostic performance in lung cancer. Results: In a training dataset, the area under the curve (AUC) values were 0.821 for HE4, 0.753 for CEA, 0.858 for RANTES, 0.867 for ApoA2, 0.830 for TTR, and 0.552 for sVCAM-1. A model using all 6 biomarkers and age yielded an AUC value of 0.986 and sensitivity of 93.2% (cutoff at specificity 94%). Applying this model to the validation dataset showed similar results. The AUC value of the model was 0.988, with sensitivity of 93.33% and specificity of 92.00% at the same cutoff point used in the validation dataset. Analyses by stages and histologic subtypes all yielded similar results. Conclusions: Combining multiple tumor and systemic inflammatory markers proved to be a valid strategy in the diagnosis of lung cancer.
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참고문헌 (28)
참고문헌 신청
National Lung Screening Trial Research Team / 2011 / Reduced lung-cancer mortality with low-dose computed tomographic screening / N Engl J Med 365:395~409
Quaife SL / 2016 / The Lung Screen Uptake Trial (LSUT): protocol for a randomised controlled demonstration lung cancer screening pilot testing a targeted invitation strategy for high risk and 'hard-to-reach'patients / BMC Cancer 16:281
Patz EF Jr / 2016 / Lung cancer incidence and mortality in national lung screening trial participants who underwent low-dose CT prevalence screening:a retrospective cohort analysis of a randomised, multicentre, diagnostic screening trial / Lancet Oncol 17:590~599
Cuca LE / 2011 / Cytotoxic effect of some natural compounds isolated from Lauraceae plants and synthetic derivatives / Biomedica 31:335~343
Zhao W / 2015 / Clinical significance of joint detection of serum CEA, SCCA, and bFGF in the diagnosis of lung cancer / Int J Clin Exp Pathol 8:9506~9511
Quaife SL / 2016 / The Lung Screen Uptake Trial (LSUT): protocol for a randomised controlled demonstration lung cancer screening pilot testing a targeted invitation strategy for high risk and 'hard-to-reach'patients / BMC Cancer 16:281
Patz EF Jr / 2016 / Lung cancer incidence and mortality in national lung screening trial participants who underwent low-dose CT prevalence screening:a retrospective cohort analysis of a randomised, multicentre, diagnostic screening trial / Lancet Oncol 17:590~599
Cuca LE / 2011 / Cytotoxic effect of some natural compounds isolated from Lauraceae plants and synthetic derivatives / Biomedica 31:335~343
Zhao W / 2015 / Clinical significance of joint detection of serum CEA, SCCA, and bFGF in the diagnosis of lung cancer / Int J Clin Exp Pathol 8:9506~9511
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