Prognostic significance of normal-sized ovary in advanced serous epithelial ovarian cancer

백이선; 김지혜; 김태중; 이정원; 김병기; 배덕수; 최철훈

추천

검색

자료유형: 학술저널

저자정보: 백이선 (성균관의대 산부인과) 김지혜 (성균관의대 산부인과) 김태중 (삼성서울병원) 이정원 (삼성서울병원) 김병기 (성균관대학교 의과대학 삼성서울병원 산부인과) 배덕수 (삼성서울병원) 최철훈 (성균관대학교)

저널정보: 대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.29 No.1

발행연도: 2018.1

수록면: 1 - 9 (9page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objective: We compared survival outcomes of advanced serous type epithelial ovarian cancer (EOC) patients with normal-sized ovaries and enlarged-ovarian tumors by propensity score matching analysis. Methods: The medical records of EOC patients treated at Samsung Medical Center between 2002 and 2015 were reviewed retrospectively. We investigated EOC patients with high grade serous type histology and International Federation of Gynecology and Obstetrics (FIGO) stage IIIB, IIIC, or IV who underwent primary debulking surgery (PDS) and adjuvant chemotherapy to identify patients with normal-sized ovaries. Propensity score matching was performed to compare patients with normal-sized ovaries to patients with enlarged-ovarian tumors (ratio, 1:3) according to age, FIGO stage, initial cancer antigen (CA)-125 level, and residual disease status after PDS. Results: Of the 419 EOC patients, 48 patients had normal-sized ovary. Patients with enlarged-ovarian tumor were younger (54.0±10.3 vs. 58.4±9.2 years, p=0.005) than those with normal-sized ovary, and there was a statistically significant difference in residual disease status between the 2 groups. In total cohort with a median follow-up period of 43 months (range, 3–164 months), inferior overall survival (OS) was shown in the normal-sized ovary group (median OS, 71.2 vs. 41.4 months; p=0.003). After propensity score matching, the group with normal-sized ovary showed inferior OS compared to the group with enlarged-ovarian tumor (median OS, 72.1 vs. 41.4 months; p=0.031). In multivariate analysis for OS, normal-sized ovary remained a significant factor. Conclusion: Normal-sized ovary was associated with poor OS compared with the common presentation of enlarged ovaries in EOC, independent of CA-125 level or residual disease.

참고문헌 (16)

참고문헌 신청

Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108

Bray F / 2012 / Global cancer transitions according to the Human Development Index (2008-2030): a population-based study / Lancet Oncol 13:790~801

Feuer GA / 1989 / Normal-sized ovary carcinoma syndrome / Obstet Gynecol 73:786~792

Wang C / 2000 / Analysis of the clinical characteristics and prognostic factors with primary normalsized epithelial ovarian carcinoma syndrome / Zhonghua Fu Chan Ke Za Zhi 35:420~422

Yamazaki T / 1995 / Normal-sized ovary carcinoma syndrome: histopathological analysis of 14 cases / Nihon Sanka Fujinka Gakkai Zasshi 47:27~34

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

백이선

소속기관 성균관의대 산부인과

주요연구분야 의약학 > 임상의학 > 산부인과학

논문수 5 이용수 0

김지혜

소속기관 성균관의대 산부인과

주요연구분야 의약학 > 임상의학 > 산부인과학

논문수 3 이용수 0

김태중

소속기관 삼성서울병원