Optimal cutoff age for predicting prognosis associated with serous epithelial ovarian cancer: what is the best age cutoff?

김지혜; 장유진; 김태중; 이정원; 김병기; 배덕수; 최철훈

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자료유형: 학술저널

저자정보: 김지혜 (성균관의대 산부인과) 장유진 (성균관의대 산부인과) 김태중 (삼성서울병원) 이정원 (삼성서울병원) 김병기 (성균관대학교) 배덕수 (삼성서울병원) 최철훈 (삼성서울병원)

저널정보: 대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.30 No.1

발행연도: 2019.1

수록면: 1 - 13 (13page)

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Objective: Elderly age is one of the poor prognostic factors in epithelial ovarian cancer (EOC), but the optimal age cut-off is not known. The present study sought to identify the ideal age cutoff that represents a negative prognostic factor in EOC, considering the geriatric assessment. Methods: Hazard ratios (HRs) with p-values were calculated using all possible age cutoffs with stage, histology, grade, optimality and comorbidities as covariates in multivariate Cox regression model. The trends of p-value and HR by age cutoff were further evaluated in a subgroup of histology and in The Cancer Genome Atlas (TCGA) dataset. In addition, propensity score-matching analysis using the identified age cutoff was performed. Results: An age of 66 years was shown to be the most significant cutoff for defining old age with independent prognostic power (HR=1.45; 95% confidence interval=1.04–2.03; p=0.027). This result was also observed with the analyses of serous histology subgroup and with the analysis of a TCGA dataset with serous EOC. In survival analysis, patients aged ≥66 years had significantly worse overall survival compared with younger individuals (56 months vs. 87 months; p=0.006), even following propensity score matching (57 vs. 78 months; p=0.038). Conclusion: An age of 66 years is the best cutoff to define elderly age in serous EOC patients considering the geriatric assessment, and this information can be used in the administration of individualized therapies in elderly EOC patients.

#Elderly #Epithelial Ovarian Cancer #Geriatric Assessment #Prognosis #Propensity Score-Matching

참고문헌 (31)

참고문헌 신청

Sopik V / 2015 / Why have ovarian cancer mortality rates declined? part I. Incidence / Gynecol Oncol 138:741~749

Torre LA / 2017 / Global cancer in women : burden and trends / Cancer Epidemiol Biomarkers Prev 26:444~457

Smith BD / 2009 / Future of cancer incidence in the United States : burdens upon an aging, changing nation / J Clin Oncol 27:2758~2765

Edwards BK / 2002 / Annual report to the nation on the status of cancer, 1973–1999, featuring implications of age and aging on U.S. cancer burden / Cancer 94:2766~2792

Yancik R / 2004 / Cancer in older persons : an international issue in an aging world / Semin Oncol 31:128~136

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김지혜

소속기관 성균관의대 산부인과

주요연구분야 의약학 > 임상의학 > 산부인과학

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장유진

소속기관 성균관의대 산부인과

주요연구분야 의약학 > 임상의학 > 산부인과학

논문수 1 이용수 0

김태중

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