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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
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- 1 - 10 (10page)
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Objective: To identify suitable diagnostic tools and evaluate the efficacy of sentinel lymphnode (SLN) biopsy for inguinal lymph node metastasis in vulvar cancer. Methods: Data from 41 patients with vulvar cancer were evaluated retrospectively, includingmagnetic resonance imaging (MRI) measurements, SLN biopsy status, groin lymph nodemetastasis, and prognosis. Results: SLN biopsy was conducted in 12 patients who had stage I to III disease. Groinlymphadenectomy was omitted in five of the nine patients with negative SLNs. All SLNnegativepatients who did not undergo groin lymphadenectomy showed no evidence ofdisease after treatment. On MRI, the long and short diameters of the inguinal node weresignificantly longer in metastasis-positive cases, compared with negative cases, in 25 patientswhose nodes were evaluated pathologically (long diameter, 12.8 mm vs. 8.8 mm, p=0.025;short diameter, 9.2 mm vs. 6.7 mm, p=0.041). The threshold of >10.0 mm for the longaxis gave a sensitivity, specificity, positive predictive value, and negative predictive value of87.5%, 70.6%, 58.3%, and 92.3%, respectively, using a binary classification test. Decisiontree analysis revealed a sensitivity, specificity, and accuracy of 87.5%, 70.6%, and 76.0%,respectively, with the threshold of >10.0 mm for the long axis on MRI. The criteria of >10.0mm for the long axis on MRI predicted an advanced stage and poorer prognosis using avalidation set of 15 cases (p=0.028). Conclusion: Minimally invasive surgery after preoperative evaluation on MRI and SLN biopsyis a feasible strategy for patients with vulvar cancer.
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참고문헌 (24)
참고문헌 신청
Meads C / 2013 / Sentinel lymph node status in vulval cancer: systematic reviews of test accuracy and decision-analytic model-based economic evaluation / Health Technol Assess 17:1~216
Meads C / 2014 / Sentinel lymph node biopsy in vulval cancer: systematic review and meta-analysis / Br J Cancer 110:2837~2846
Homesley HD / 1993 / Prognostic factors for groin node metastasis in squamous cell carcinoma of the vulva(a Gynecologic Oncology Group study) / Gynecol Oncol 49:279~283
Kataoka MY / 2010 / The accuracy of magnetic resonance imaging in staging of vulvar cancer: a retrospective multi-centre study / Gynecol Oncol 117:82~87
Gonzalez Bosquet J / 2003 / Risk of occult inguinofemoral lymph node metastasis from squamous carcinoma of the vulva / Int J Radiat Oncol Biol Phys 57:419~424
Meads C / 2014 / Sentinel lymph node biopsy in vulval cancer: systematic review and meta-analysis / Br J Cancer 110:2837~2846
Homesley HD / 1993 / Prognostic factors for groin node metastasis in squamous cell carcinoma of the vulva(a Gynecologic Oncology Group study) / Gynecol Oncol 49:279~283
Kataoka MY / 2010 / The accuracy of magnetic resonance imaging in staging of vulvar cancer: a retrospective multi-centre study / Gynecol Oncol 117:82~87
Gonzalez Bosquet J / 2003 / Risk of occult inguinofemoral lymph node metastasis from squamous carcinoma of the vulva / Int J Radiat Oncol Biol Phys 57:419~424
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