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논문 기본 정보

자료유형
학술저널
저자정보
Ryo Katsumata (Division of Gastroenterology Kawasaki Medical School Kurashiki Okayama Japan) Manabu Ishii (Division of Gastroenterology Kawasaki Medical School Kurashiki Okayama Japan) Suni Lee (Department of Hygiene Kawasaki Medical School Kurashiki Okayama Japan) Yukiko Handa (Handa Clinic of Internal Medicine Wakayama Japan) Takahisa Murao (Division of Gastroenterology Kawasaki Medical School Kurashiki Okayama Japan) Minoru Fujita (Division of Gastroenterology Kawasaki Medical School Kurashiki Okayama Japan) Hiroshi Matsumoto (Division of Gastroenterology Kawasaki Medical School Kurashiki Okayama Japan) Takemi Otsuki (Department of Hygiene Kawasaki Medical School Kurashiki Okayama Japan) Akiko Shiotani (Division of Gastroenterology Department of Internal Medicine Kawasaki Medical School Kurashiki)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.3
발행연도
2018.1
수록면
415 - 421 (7page)

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Background/Aims Food interaction, including food hypersensitivity, plays a key role in the pathogenesis of irritable bowel syndrome with diarrhea (IBS-D). Since only a few studies have been reported about the relationship between food hypersensitivity and IBS-D, we elucidate the prevalence of serological food hypersensitivity in patients with IBS-D and the characteristics of gastrointestinal symptoms and serum cytokine profiles in patients with IBS-D and serological food hypersensitivity. Methods Immunoglobulin E (Ig E)-mediated serological food hypersensitivity and serum cytokine levels were evaluated using the multiple allergen simultaneous test evaluating food allergen-specific serum IgE and Luminex Milliplex Panel containing multiple fluorescence-labeled beads. Class 2 or above was considered as IgE-mediated food hypersensitivity positive. The gastrointestinal symptom rating scale was used to evaluate symptoms. Results We enrolled 92 subjects, including 60 with IBS-D and 32 healthy controls. The percentages of patients with IgE-mediated serological food hypersensitivity were not significantly different between the groups (controls = 28.1% and IBS-D = 33.3%). Serum IL-1β, IL-6, IL-8, macrophage inflammatory protein-1alpha, and TNF-α levels were higher in patients with IBS-D than in controls. Serum concentration of TNF-α (43.4 vs 21.8 pg/mL, P = 0.009) was higher in patients with IBS-D without IgE-mediated serological food hypersensitivity than those with food hypersensitivity. Conclusions One-third of Japanese patients with IBS-D showed IgE-mediated serological food hypersensitivity. The serum cytokine profile differed and was characterized by lower inflammatory cytokine levels in IBS-D with IgE-mediated serological food hypersensitivity. Serological test regarding IgE-mediated food hypersensitivity can detect a certain cluster of IBS-D.

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참고문헌 (39)

참고문헌 신청
Enck P / 2016 / Irritable bowel syndrome / Nat Rev Dis Primers 2:16014 Crossref Drossman DA / 2016 / Functional Gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV / Gastroenterology 150:1262~1279 Crossref Saha L / 2014 / Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine / World J Gastroenterol 20:6759~6773 Crossref Hayes PA / 2014 / Irritable bowel syndrome: the role of food in pathogenesis and management / Gastroenterol Hepatol 10:164~174 google schola Angela Rizzi / 2017 / Irritable Bowel Syndrome and Nickel Allergy: What Is the Role of the Low Nickel Diet? Angela Rizzi, Eleonora Nucera, Lucrezia Laterza, Eleonora Gaetani, Venanzio Valenza, Giuseppe M Corbo, / Journal of Neurogastroenterology and Motility (JNM) 23(1):101~108 dbpia

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