Irritable Bowel Syndrome and Nickel Allergy: What Is the Role of the Low Nickel Diet? Angela Rizzi, Eleonora Nucera, Lucrezia Laterza, Eleonora Gaetani, Venanzio Valenza, Giuseppe M Corbo,

Angela Rizzi; Eleonora Nucera; Lucrezia Laterza; Eleonora Gaetani; Venanzio Valenza; Giuseppe M Corbo; Riccardo Inchingolo; Alessandro Buonomo; Domenico Schiavino; Antonio Gasbarrini

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저자정보: Angela Rizzi (Fondazione Policlinico Universitario A. Germelli Università Cattolica del Sacro Cuore Rome Italy) Eleonora Nucera (Fondazione Policlinico Universitario A. Germelli Università Cattolica del Sacro Cuore Rome Italy) Lucrezia Laterza (Fondazione Policlinico Universitario A. Germelli Università Cattolica del Sacro Cuore Rome Italy) Eleonora Gaetani (Fondazione Policlinico Universitario A. Germelli Università Cattolica del Sacro Cuore Rome Italy) Venanzio Valenza (Fondazione Policlinico Universitario A. Germelli Università Cattolica del Sacro Cuore Rome Italy) Giuseppe M Corbo (Fondazione Policlinico Universitario A. Germelli Università Cattolica del Sacro Cuore Rome Italy) Riccardo Inchingolo (Fondazione Policlinico Universitario A. Germelli Università Cattolica del Sacro Cuore Rome Italy) Alessandro Buonomo (Fondazione Policlinico Universitario A. Germelli Università Cattolica del Sacro Cuore Rome Italy) Domenico Schiavino (Fondazione Policlinico Universitario A. Germelli Università Cattolica del Sacro Cuore Rome Italy) Antonio Gasbarrini (Fondazione Policlinico Universitario A. Germelli Università Cattolica del Sacro Cuore Rome Italy)

저널정보: 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.23 No.1

발행연도: 2017.1

수록면: 101 - 108 (8page)

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Background/Aims: Irritable bowel syndrome (IBS) is characterized by chronic abdominal pain or discomfort accompanied by abnormal bowel movements. In sensitized subjects, ingested nickel (Ni) may induce gastrointestinal symptoms similar to IBS, in addition to typical systemic cutaneous lesions (systemic nickel allergy syndrome [SNAS]). A low nickel diet could improve the systemic manifestations. We evaluated prevalence of nickel allergy in IBS and effects of low Ni diet on (1) gastrointestinal symptoms control, (2) intestinal barrier function, (3) quality of life, and (4) psychological status of patients with IBS and Ni-sensitized patients. Methods: Twenty consecutive patients affected by IBS and suspected SNAS underwent intestinal permeability tests. Gastrointestinal symptoms were evaluated using the visual analogue scale before and after 3 months low Ni diet. Subjects with increased intestinal permeability at baseline repeated nuclear examination after the diet. Results: The most frequent profile was diarrhea-predominant IBS (8/20). The low Ni diet induced a significant and constant improvement of gastrointestinal symptoms and an equally significant improvement of visual analogue scale. Mean urinary output of 51Chromium ethylene-diamine-tetra-acetate (51Cr-EDTA) was 5.91%/24 hr (± 2.08), significantly different from the control group (2.20%/24 hr ± 0.60, P < 0.0001). Conclusion: This pilot study shows that low Ni diet improves gastrointestinal symptoms in patients with IBS and SNAS.

참고문헌 (32)

참고문헌 신청

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