지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.22 No.2
- 발행연도
- 2016.1
- 수록면
- 272 - 281 (10page)
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초록· 키워드
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Background/AimsThe functional variant (rs56109847) in the 3′-untranslated regions (3′-UTR) of the serotonin receptor 3E (HTR3E) gene is associated withfemale diarrhea predominant irritable bowel syndrome (IBS-D) in British populations. However, the relationship of the polymorphism bothto HTR3E expression in the intestine and to the occurrence of Chinese functional gastrointestinal disorders has yet to be examined. MethodsPolymerase chain reaction amplification and restriction fragment length polymorphism analyses were employed to detectpolymorphisms among Chinese Han women, particularly 107 patients with IBS-D, 99 patients with functional dyspepsia (FD), 115patients with mixed IBS and 69 patients with IBS-D + FD. We also assessed microRNA-510 (miR-510) and HTR3E expression in humancolonic mucosal tissues with immunohistochemistry and other methods. Dual-luciferase reporter assays were conducted to examinethe binding ability of miR-510 and HTR3E 3′-UTR. ResultsGenotyping data showed the variant rs56109847 was significantly associated with IBS-D, but not with FD, mixed-IBS, or FD + IBS-D. HTR3E was abundantly expressed around the colonic mucosal glands but less expressed in the stroma. miR-510 expression decreased,whereas HTR3E expression increased in the colonic mucosal tissue of patients with IBS-D compared with those in controls. HTR3Eexpression was significantly higher in patients with the GA genotype than that in patients with the GG genotype. The single-nucleotidepolymorphisms disrupted the binding site of miR-510 and significantly upregulated luciferase expression in HEK293 and HT-29 cells. ConclusionsThe single-nucleotide polymorphisms rs56109847 led to reduced microRNA binding and overexpression of the target gene in intestinalcells, thereby increasing IBS-D risk in the Chinese Han population. The decreased expression of miR-510 might contribute to IBS-D.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Futagami S / 2013 / Impact of coexisting irritable bowel syndrome and non-erosive reflux disease on postprandial abdominal fullness and sleep disorders in functional dyspepsia / J Nippon Med Sch 80:362~370
Longstreth GF / 2006 / Functional bowel disorders / Gastroenterology 130:1480~1491
Tack J / 1998 / Role of impaired gastric accommodation to a meal in functional dyspepsia / Gastroenterology 115:1346~1352
Holtmann G / 1998 / Altered vagal and intestinal mechanosensory function in chronic unexplained dyspepsia / Gut 42:501~506
Nourrisson C / 2014 / Blastocystis is associated with decrease of fecal microbiota protective bacteria: comparative analysis between patients with irritable bowel syndrome and control subjects / PLoS One 9:e111868
Longstreth GF / 2006 / Functional bowel disorders / Gastroenterology 130:1480~1491
Tack J / 1998 / Role of impaired gastric accommodation to a meal in functional dyspepsia / Gastroenterology 115:1346~1352
Holtmann G / 1998 / Altered vagal and intestinal mechanosensory function in chronic unexplained dyspepsia / Gut 42:501~506
Nourrisson C / 2014 / Blastocystis is associated with decrease of fecal microbiota protective bacteria: comparative analysis between patients with irritable bowel syndrome and control subjects / PLoS One 9:e111868
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