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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 278 - 286 (9page)
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초록· 키워드
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Agmatine is a decarboxylated arginine by arginine decarboxylase. Agmatine is known to be a neuroprotective agent. It has been re- ported that agmatine works as a NMDA receptor blocker or a competitive nitric oxide synthase inhibitor in CNS injuries. In spinal cord injury, agmatine showed reduction of neuropathic pain, improvement of locomotor function, and neuroprotection. Macrophage is a key cellular component in neuroinflammation, a major cause of impairment after spinal cord injury. Macrophage has subtypes, M1 and M2 macrophages. M1 macrophage induces a pro-inflammatory response, but M2 inspires an anti-inflammatory response. In this study, it was clarified whether the neuroprotective effect of agmatine is related with the modulation of macrophage subdivision after spinal cord injury. Spinal cord injury was induced in rats with contusion using MASCIS. Animals received agmatine (100 mg/ kg, IP) daily for 6 days beginning the day after spinal cord injury. The proportion of M1 and M2 macrophages are confirmed with immunohistochemistry and FACS. CD206+ & ED1+ cells were counted as M2 macrophages. The systemic treatment of agmatine increased M2 macrophages caudal side to epicenter 1 week after spinal cord injury in immunohistochemistry. M2 macrophage re- lated markers, Arginase-1 and CD206 mRNA, were increased in the agmatine treatment group and M2 macrophage expressing and stimulated cytokine, IL-10 mRNA, also was significantly overexpressed by agmatine injection. Among BMPs, BMP2/4/7, agmatine significantly increased only the expression of BMP2 known to reduce M1 macrophage under inflammatory status. These results sug- gest that agmatine reduces impairment after spinal cord injury through modulating the macrophage phenotype.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Plemel JR / 2014 / Immune modulatory therapies for spinal cord injury--past, present and future / Exp Neurol 258:91~104
Hayakawa K / 2014 / Lipopolysaccharide preconditioning facilitates M2 activation of resident microglia after spinal cord injury / J Neurosci Res 92:1647~1658
Kigerl KA / 2009 / Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord / J Neurosci 29:13435~13444
Shechter R / 2013 / Recruitment of beneficial M2macrophages to injured spinal cord is orchestrated by remote brain choroid plexus / Immunity 38:555~569
Ma SF / 2015 / Adoptive transfer of M2 macrophages promotes locomotor recovery in adult rats after spinal cord injury / Brain Behav Immun 45:157~170
Hayakawa K / 2014 / Lipopolysaccharide preconditioning facilitates M2 activation of resident microglia after spinal cord injury / J Neurosci Res 92:1647~1658
Kigerl KA / 2009 / Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord / J Neurosci 29:13435~13444
Shechter R / 2013 / Recruitment of beneficial M2macrophages to injured spinal cord is orchestrated by remote brain choroid plexus / Immunity 38:555~569
Ma SF / 2015 / Adoptive transfer of M2 macrophages promotes locomotor recovery in adult rats after spinal cord injury / Brain Behav Immun 45:157~170
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