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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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- 1 - 5 (5page)
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Antibody-mediated rejection (AMR) is a rare event in liver transplantation compared to other solid organs such as the kidney and heart because of the different immunologic reactions in the liver and it ability to compensate for damage. Although it is not easy to define the histological features that help diagnosis because of its rarity, a few histologic features such as portal eosinophilia with eosinophilic endothelialitis have been reported as useful for diagnosis of acute AMR in presensitized patients. C4d staining is not a good indicator of AMR in liver grafts because of its low sensitivity and specificity. AMR is an emerging cause of chronic graft failure, especially in high risk patients having preformed or de novo donor specific alloantibodies (DSA). Some histologic parameters including interface hepatitis, lobular inflammation, portal collagenation, portal venopathy, and sinusoidal fibrosis, have been suggested as chronic AMR to predict graft fibrosis and survival in DSA positive patients. In conclusion, recent studies have resulted in the histological diagnostic criteria of AMR becoming more specific; however, confirmation of AMR still requires strong clinical evidence for alloantibodies.
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참고문헌 (19)
참고문헌 신청
Nakamura K / 1993 / Liver allograft rejection in sensitized recipients. Observations in a clinically relevant small animal model / Am J Pathol 142:1383~1391
Demetris AJ / 1992 / Immunopathology of antibodies as effectors of orthotopic liver allograft rejection / Semin Liver Dis 12:51~59
O'Leary JG / 2014 / Acute liver allograft antibody-mediated rejection : an inter-institutional study of significant histopathological features / Liver Transpl 20:1244~1255
Kozlowski T / 2012 / Sinusoidal C4d deposits in liver allografts indicate an antibody-mediated response : diagnostic considerations in the evaluation of liver allografts / Liver Transpl 18:641~658
Bellamy CO / 2007 / C4d immunopositivity is uncommon in ABO-compatible liver allografts, but correlates partially with lymphocytotoxic antibody status / Histopathology 50:739~749
Demetris AJ / 1992 / Immunopathology of antibodies as effectors of orthotopic liver allograft rejection / Semin Liver Dis 12:51~59
O'Leary JG / 2014 / Acute liver allograft antibody-mediated rejection : an inter-institutional study of significant histopathological features / Liver Transpl 20:1244~1255
Kozlowski T / 2012 / Sinusoidal C4d deposits in liver allografts indicate an antibody-mediated response : diagnostic considerations in the evaluation of liver allografts / Liver Transpl 18:641~658
Bellamy CO / 2007 / C4d immunopositivity is uncommon in ABO-compatible liver allografts, but correlates partially with lymphocytotoxic antibody status / Histopathology 50:739~749
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