Clinicohematological parameters and outcomes in a cohort of chronic lymphocytic leukemia patients with Deletion 17p from Pakistan

Rafia Mahmood; Saleem Ahmed Khan; Chaudhry Altaf; Hamid Saeed Malik; Muhammad Tahir Khadim

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저자정보: Rafia Mahmood (Armed Forces Institute of Pathology) Saleem Ahmed Khan (Armed Forces Institute of Pathology) Chaudhry Altaf (Armed Forces Institute of Pathology) Hamid Saeed Malik (Armed Forces Institute of Pathology) Muhammad Tahir Khadim (Armed Forces Institute of Pathology)

저널정보: 대한혈액학회 Blood Research Blood Research Vol.53 No.4

발행연도: 2018.1

수록면: 276 - 280 (5page)

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BackgroundChronic lymphocytic leukemia (CLL) exhibits profound heterogeneity in its clinical course. Its clinicohematological and cytogenetic features play a significant role in de-termining the clinical course and in predicting the treatment response and prognosis. In this context, 17p deletion is known to predict a poor prognosis, as these cases are re-fractory to conventional therapy. This study aimed to evaluate the clinicohematological characteristics, outcomes, and prognostic factors among CLL patients with and without del 17p in Pakistan.MethodsThis prospective observational study was conducted at the Department of Haematology, Armed Forces Institute of Pathology (Rawalpindi, Pakistan) between January 2013 and December 2017. Patients were diagnosed based on the International Workshop on Chronic Lymphocytic Leukaemia IWCLL criteria, their clinicohematological parameters were recorded, and cytogenetic analyses were performed. The time from diagnosis to treatment and the 2-year overall survival rate were also evaluated.ResultsWe evaluated 130 CLL cases, including 24 patients (18.5%) with del 17p, who included 18 men (75%) and 6 women (25%). The median age was 68 years. Binet stage C was de-tected at the presentation in 16 patients (67%). Treatment was administered to 14 patients (70%) at a median interval of 11 months (range, 0‒28 mo) after diagnosis. The overall response rate was 64.3%, the median event-free survival was 9 months (range, 1‒23 mo), and the 2-year overall survival rate was 65%.ConclusionDel 17p is relatively common in Pakistan, and patients harboring this deletion had poor treatment response and survival outcomes.

참고문헌 (22)

참고문헌 신청

Nabhan C / 2014 / Chronic lymphocytic leukemia : a clinical review / JAMA 312:2265~2276

Eid OM / 2014 / Detection of cytogenetics abnormalities in chronic lymphocytic leukemia using FISH technique and their prognostic impact / Gulf J Oncolog 1:68~75

Teimori H / 2013 / FISH analysis for del6q21 and del17p13 in B-cell chronic lymphocytic leukemia in Iranians / Iran Red Crescent Med J 15:107~112

Parker TL / 2011 / Chronic lymphocytic leukemia : prognostic factors and impact on treatment / Discov Med 11:115~123

Sutton LA / 2015 / Deciphering the molecular landscape in chronic lymphocytic leukemia : time frame of disease evolution / Haematologica 100:7~16

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