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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 113 - 121 (9page)
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BackgroundThe association between baseline renal impairment (RI) and the prognosis of diffuse large B-cell lymphoma (DLBCL) was previously not defined. The aim of this study was to evaluate the prognostic value of RI in patients with DLBCL treated with three-weekly rituximab plus cyclophosphamide, Adriamycin, vincristine, and prednisolone immunochemotherapy (R-CHOP21).MethodsPatients with newly diagnosed de novo DLBCLs treated with ≥1 cycle of R-CHOP21 were analyzed retrospectively. Pretreatment blood samples were collected and the glomerular filtration rate (GFR) was calculated. RI was defined by a GFR of ＜60 mL/min/1.73 m2 ac-cording to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula.ResultsOf the 185 patients enrolled in the present study, 19 patients (10.3%) had RI. The reasons for baseline RI were pre-existing CKD (N=5), acute kidney injury due to either obstruction (N=2) or electrolyte imbalance (N=2) related to DLBCL, and undefined causes (N=10). Patients with baseline RI showed inferior overall survival (OS) compared to those without RI (P＜0.001). In multivariate analysis, RI was identified as an International Prognostic Index (IPI)-independent prognostic indicator. A baseline hemoglobin level of ＜10 g/dL and the presence of RI effectively discriminated a portion of the patients with far inferior event-free survival and OS among the patients having high or high-intermediate risk can-cers according to either the standard- or the National Comprehensive Cancer Network-IPI.ConclusionPretreatment RI was an independent prognostic marker for inferior OS in patients with DLBCL treated with R-CHOP21 immunochemotherapy.
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참고문헌 (29)
참고문헌 신청
Launay-Vacher V / 2010 / Epidemiology of chronic kidney disease in cancer patients: lessons from the IRMA study group / Semin Nephrol 30:548~556
Launay-Vacher V / 2013 / Cancer and the kidney: individualizing dosage according to renal function / Ann Oncol 24:2713~2714
Launay-Vacher V / 2007 / Prevalence of Renal Insufficiency in cancer patients and implications for anticancer drug management: the renal insufficiency and anticancer medications (IRMA) study / Cancer 110:1376~1384
Kurita GP / 2015 / Renal function and symptoms/adverse effects in opioid-treated patients with cancer / Acta Anaesthesiol Scand 59:1049~1059
Durand JP / 2012 / Validation of the Cochin Risk Index Score (CRIS) for life expectancy prediction in terminally ill cancer patients / Support Care Cancer 20:857~864
Launay-Vacher V / 2013 / Cancer and the kidney: individualizing dosage according to renal function / Ann Oncol 24:2713~2714
Launay-Vacher V / 2007 / Prevalence of Renal Insufficiency in cancer patients and implications for anticancer drug management: the renal insufficiency and anticancer medications (IRMA) study / Cancer 110:1376~1384
Kurita GP / 2015 / Renal function and symptoms/adverse effects in opioid-treated patients with cancer / Acta Anaesthesiol Scand 59:1049~1059
Durand JP / 2012 / Validation of the Cochin Risk Index Score (CRIS) for life expectancy prediction in terminally ill cancer patients / Support Care Cancer 20:857~864
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