지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 298 - 306 (9page)
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초록· 키워드
오류제보하기
Purpose: The aim of this animal study was to evaluate the safety and feasibility of a portable,ultrasonography-guided, high-intensity focused ultrasound (USg-HIFU) system to treat thepancreas. Methods: Eight swine were included. Using a portable HIFU device (ALPIUS 900, AlpinionMedical Systems), ablations were performed on the pancreas in vivo. Different acousticintensities were applied (1.7 kW/cm2or 1.5 kW/cm2, n=2 [group A for a pilot study]; 1.5 kW/cm2, n=3 [group B]; and 1.2 kW/cm2, n=3 [group C]). Magnetic resonance imaging (MRI) wasperformed immediately (group A) or 7 days (groups B and C) after HIFU treatment. In groups Band C, serum amylase and lipase levels were measured on days 0 and 7, and performance statuswas observed every day. Necropsy was performed on days 0 (group A) or 7 (groups B and C) toassess the presence of unintended injuries and to obtain pancreatic and peripancreatic tissue forhistological analysis. Results: Ablation was noted in the pancreas in all swine on MRI, and all pathologic specimensshowed coagulation necrosis in the treated area. The mean ablation areas on MRI were85.3±38.1 mm2, 90.7±21.2 mm2, and 54.4±30.6 mm2in groups A, B, and C, respectively(P>0.05). No animals showed evidence of complications, except for one case of a pseudocyst ingroup B. Conclusion: This study showed that pancreas ablation using a portable USg-HIFU system may besafe and feasible, and that coagulation necrosis of the pancreas was successfully achieved with arange of acoustic intensities.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Stewart BW / 2014 / World cancer report 2014
Konstantinidis IT / 2013 / Pancreatic ductal adenocarcinoma: is there a survival difference for R1 resections versus locally advanced unresectable tumors? What is a "true" R0 resection? / Ann Surg 257:731~736
Hariharan D / 2008 / Analysis of mortality rates for pancreatic cancer across the world / HPB (Oxford) 10:58~62
von Wichert G / 2008 / Palliative treatment of pancreatic cancer / J Dig Dis 9:1~7
Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66:7~30
Konstantinidis IT / 2013 / Pancreatic ductal adenocarcinoma: is there a survival difference for R1 resections versus locally advanced unresectable tumors? What is a "true" R0 resection? / Ann Surg 257:731~736
Hariharan D / 2008 / Analysis of mortality rates for pancreatic cancer across the world / HPB (Oxford) 10:58~62
von Wichert G / 2008 / Palliative treatment of pancreatic cancer / J Dig Dis 9:1~7
Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66:7~30
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