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논문 기본 정보

자료유형
학술저널
저자정보
Yeo-Jeong Song (Inje University College of Medicine) Sang Jin Ha (University of Ulsan College of Medicine) Dong Seok Lee (University of Ulsan College of Medicine) Woo-Dae Bang (University of Ulsan College of Medicine) 신동금 (한림대학교부속강남성심병원) Yeongmin Woo (University of Ulsan College of Medicine) Sangsig Cheong (University of Ulsan College of Medicine) Sang-Yong Yoo (University of Ulsan College of Medicine)
저널정보
대한심장학회 Korean Circulation Journal Korean Circulation Journal Vol.48 No.10
발행연도
2018.1
수록면
906 - 916 (11page)

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Background and Objectives Ergonovine stress echocardiography (ErgECHO) has been proposed as a noninvasive tool for the diagnosis of coronary vasospasm. However, concern over the safety of ErgECHO remains. This study was undertaken to investigate the safety and prognostic value of ErgECHO in a large population. Methods We studied 3,094 consecutive patients from a single-center registry who underwent ErgECHO from November 2002 to June 2009. Medical records, echocardiographic data, and laboratory findings obtained from follow-up periods were analyzed. Results The overall positive rate of ErgECHO was 8.6%. No procedure-related mortality or myocardial infarction (MI) occurred. Nineteen patients (0.6%) had transient symptomatic complications during ErgECHO including one who was successfully resuscitated. Cumulative major adverse cardiac events (MACEs) occurred in 14.0% and 5.1% of the patients with positive and negative ErgECHO results, respectively (p<0.001) at a median follow-up of 10.5 years. Cox regression survival analyses revealed that male sex, age, presence of diabetes, total cholesterol level of >220 mg/dL, and positive ErgECHO result itself were independent factors associated with MACEs. Conclusions ErgECHO can be performed safely by experienced physicians and its positive result may be an independent risk factor for long-term adverse outcomes. It may also be an alternative tool to invasive ergonovine-provoked coronary angiography for the diagnosis of vasospastic angina.

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