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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 472 - 480 (9page)
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초록· 키워드
오류제보하기
Background and Objectives: There is controversy surrounding whether or not high dose statin administration before percutaneous coronary intervention (PCI) decreases peri-procedural microvascular injury. We performed a prospective randomized study to investigate the mechanisms and effects of pre-treatment high dose atorvastatin on myocardial damage in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing PCI. Subjects and Methods: Seventy seven patients with NSTE-ACS were randomly assigned to either the high dose group (atorvastatin 80 mg loading 12 to 24 h before PCI with a further 40 mg loading 2 h before PCI, n=39) or low dose group (atorvastatin 10 mg administration 12 to 24 h before PCI, n=38). Index of microcirculatory resistance (IMR) was measured after stent implantation. Creatine kinasemyocardial band (CK-MB) and high sensitivity C-reactive protein (CRP) levels were measured before and after PCI. Results: The baseline characteristics were not different between the two patient groups. Compared to the low dose group, the high dose group had lower post PCI IMR (14.1±5.0 vs. 19.2±9.3 U, p=0.003). Post PCI CK-MB was also lower in the high dose group (median: 1.40 ng/mL (interquartile range [IQR: 0.75 to 3.45] vs. 4.00 [IQR: 1.70 to 7.37], p=0.002) as was the post-PCI CRP level (0.09 mg/dL [IQR: 0.04 to 0.16] vs. 0.22 [IQR: 0.08 to 0.60], p=0.001). Conclusion: Pre-treatment with high dose atorvastatin reduces peri-PCI microvascular dysfunction verified by post-PCI IMR and exerts an immediate anti-inflammatory effect in patients with NSTE-ACS.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Levine GN / 2011 / 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions / J Am Coll Cardiol 58:e44~e122
Prasad A / 2006 / Isolated elevation in troponin T after percutaneous coronary intervention is associated with higher long-term mortality / J Am Coll Cardiol 48:1765~1770
Fuchs S / 2000 / Prognostic value of cardiac troponin-I levels following catheter-based coronary interventions / Am J Cardiol 85:1077~1082
Patti G / 2007 / Atorvastatin pretreatment improves outcomes in patients with acute coronary syndromes undergoing early percutaneous coronary intervention: results of the ARMYDA-ACS randomized trial / J Am Coll Cardiol 49:1272~1278
Briguori C / 2009 / Novel approaches for preventing or limiting events (Naples) II trial: impact of a single high loading dose of atorvastatin on periprocedural myocardial infarction / J Am Coll Cardiol 54:2157~2163
Prasad A / 2006 / Isolated elevation in troponin T after percutaneous coronary intervention is associated with higher long-term mortality / J Am Coll Cardiol 48:1765~1770
Fuchs S / 2000 / Prognostic value of cardiac troponin-I levels following catheter-based coronary interventions / Am J Cardiol 85:1077~1082
Patti G / 2007 / Atorvastatin pretreatment improves outcomes in patients with acute coronary syndromes undergoing early percutaneous coronary intervention: results of the ARMYDA-ACS randomized trial / J Am Coll Cardiol 49:1272~1278
Briguori C / 2009 / Novel approaches for preventing or limiting events (Naples) II trial: impact of a single high loading dose of atorvastatin on periprocedural myocardial infarction / J Am Coll Cardiol 54:2157~2163
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