지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 286 - 297 (12page)
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초록· 키워드
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Purpose: To investigate the effects of cavernous nerve injury (CNI) on gene expression profiles in the cavernosal tissue of a CNI-induced erectile dysfunction (ED) model and to provide a basis for future investigations to discover potential target genes for ED treatment. Materials and Methods: Young adult rats were divided randomly into 2 groups: sham operation and bilateral CN resection. At 12 weeks after CNI we measured erectile responses and performed microarray experiments and gene set enrichment analysis to reveal gene signatures that were enriched in the CNI-induced ED model. Alterations in gene signatures were compared with those in the diabetes-induced ED model. The diabetic-induced ED data is taken from GSE2457. Results: The mean ratio of intracavernosal pressure/blood pressure for the CNI group (0.54±0.4 cmH2O) was significantly lower than that in the sham operation group (0.73±0.8 cmH2O, p<0.05). Supervised and unsupervised clustering analysis showed that the diabetes- and CNI-induced ED cavernous tissues had different gene expression profiles from normal cavernous tissues. We identified 46 genes that were upregulated and 77 genes that were downregulated in both the CNI- and diabetes-induced ED models. Conclusions: Our genome-wide and computational studies provide the groundwork for understanding complex mechanisms and molecular signature changes in ED.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Jemal A / 2010 / Cancer statistics, 2010 / CA Cancer J Clin 60:277~300
Noldus J / 2002 / Patient-reported sexual function after nerve-sparing radical retropubic prostatectomy / Eur Urol 42:118~124
Sanda MG / 2008 / Quality of life and satisfaction with outcome among prostate-cancer survivors / N Engl J Med 358:1250~1261
User HM / 2003 / Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction / J Urol 169:1175~1179
Mullerad M / 2006 / Functional sequelae of cavernous nerve injury in the rat: is there model dependency / J Sex Med 31:77~83
Noldus J / 2002 / Patient-reported sexual function after nerve-sparing radical retropubic prostatectomy / Eur Urol 42:118~124
Sanda MG / 2008 / Quality of life and satisfaction with outcome among prostate-cancer survivors / N Engl J Med 358:1250~1261
User HM / 2003 / Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction / J Urol 169:1175~1179
Mullerad M / 2006 / Functional sequelae of cavernous nerve injury in the rat: is there model dependency / J Sex Med 31:77~83
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