지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.71 No.2
- 발행연도
- 2018.1
- 수록면
- 113 - 119 (7page)
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초록· 키워드
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Background: The concept of the effect-site concentration of anesthetic agents is important. The effect compartment model can be explained using the concepts of effect-site concentration and effect-site equilibration rate constant (ke0). This study confirms that the time-to-peak effect (tpe) can be measured easily in clinical practice by applying a priming dose and train-of-four (TOF) during general anesthesia induction, and ke0 can be calculated from the tpe of the four muscle relaxants that are commonly used in general anesthesia. Methods: Eighty patients who received general anesthesia were divided into the succinylcholine, rocuronium, atracurium, or vecuronium groups. Priming doses of muscle relaxants were administered. The effects of muscle relaxants were quantified by recording the twitch response of the adductor pollicis muscle after stimulating the ulnar nerve. The tpe was measured at the lowest TOF value. ke0 was calculated from the measured tpe. Results: The ke0 values of the succinylcholine, rocuronium, atracurium, and vecuronium groups were 0.076 (0.030)/min, 0.228 (0.122)/min, 0.062 (0.011)/min, and 0.077 (0.019)/min, respectively. Conclusions: It is possible to estimate ke0 from the tpe of muscle relaxants using a priming dose and TOF during general anesthesia induction.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
한동우 / 2014 / 마취 영역에서 약동, 약력 모형화 / Anesthesia and Pain Medicine 9(2):77~86
Cortinez LI / 2007 / Estimation of the plasma effect-site equilibration rate constant (ke0) of rocuronium by the time of maximum effect: a comparison with non-parametric and parametric approaches / Br J Anaesth 99:679~685
Minto CF / 2003 / Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics / Anesthesiology 99:324~333
van Meurs WL / 1998 / Pharmacokinetic-pharmacodynamic model for educational simulations / IEEE Trans Biomed Eng 45:582~590
박종국 / 2006 / 마취유도동안 지속정맥주입으로 근이완제를 투여할 때 약역학과 삽관조건의 비교 / Korean Journal of Anesthesiology 50(3):250~255
Cortinez LI / 2007 / Estimation of the plasma effect-site equilibration rate constant (ke0) of rocuronium by the time of maximum effect: a comparison with non-parametric and parametric approaches / Br J Anaesth 99:679~685
Minto CF / 2003 / Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics / Anesthesiology 99:324~333
van Meurs WL / 1998 / Pharmacokinetic-pharmacodynamic model for educational simulations / IEEE Trans Biomed Eng 45:582~590
박종국 / 2006 / 마취유도동안 지속정맥주입으로 근이완제를 투여할 때 약역학과 삽관조건의 비교 / Korean Journal of Anesthesiology 50(3):250~255
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