Impact of hydroxyethyl starch 70/0.5 on acute kidney injury after gastroenterological surgery

Takeshi Umegaki; Takeo Uba; Chisato Sumi; Sachiyo Sakamoto; Sachiko Jomura; Kiichi Hirota; Koh Shingu

추천

검색

자료유형: 학술저널

저자정보: Takeshi Umegaki (Department of Anesthesiology Hirakata Hospital) Takeo Uba (Department of Anesthesiology Hirakata Hospital) Chisato Sumi (Department of Anesthesiology Hirakata Hospital) Sachiyo Sakamoto (Department of Anesthesiology Hirakata Hospital) Sachiko Jomura (Department of Anesthesiology Hirakata Hospital) Kiichi Hirota (Department of Anesthesiology Hirakata Hospital) Koh Shingu (Department of Anesthesiology Hirakata Hospital)

저널정보: 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.69 No.5

발행연도: 2016.1

수록면: 460 - 467 (8page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Previous studies reported a higher mortality risk and a greater need for renal replacement therapy in patients administered hydroxyethyl starch (HES) rather than other fluid resuscitation preparations. In this study, we investigated the association between 6% HES 70/0.5 use and postoperative acute kidney injury (AKI) in gastroenterological surgery patients. Methods: We conducted retrospective full-cohort and propensity-score-based analyses of patients who underwent gastroenterological surgery between June 2011 and August 2013 in a Japanese university hospital. The study sample comprised 66 AKI and 2,152 non-AKI patients in the full-cohort analysis and 35 AKI and 1,269 non-AKI patients in the propensity-score-based analysis. Propensity scores were calculated using an ordered logistic regression model in which the dependent variable comprised three groups based on HES infusion volumes (0, 1–999, and ≥ 1,000 ml). The association between HES groups and postoperative AKI incidence was analyzed using multiple logistic regression models. Other candidate independent variables included patient characteristics and intraoperative measures. Results: In the full-cohort analysis, 40 (60.6%) AKI patients were diagnosed as “risk,” 15 (22.7%) as “injury,” and 11 (16.7%) as “failure.” In the propensity-score-based analysis, the corresponding values were 22 (62.9%), 8 (22.9%), and 5 (14.3%). There was no significant association between total infused HES and postoperative AKI incidence in either the full-cohort or the propensity-score-based analysis (P = 0.168 and P = 0.42, respectively). Conclusions: AKI incidence was not associated with clinical 6% HES 70/0.5 administration in gastroenterological surgery patients treated at a single center.

참고문헌 (19)

참고문헌 신청

Konno H / 2013 / Annual report of National Clinical Database in Gastroenterological Surgery 2011–2012 (in Japanese) / Nihon Shokaki Geka Gakkai Zasshi 46:952~963

Perner A / 2012 / Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis / N Engl J Med 367:124~134

Myburgh JA / 2012 / Hydroxyethyl starch or saline for fluid resuscitation in intensive care / N Engl J Med 367:1901~1911

Brunkhorst FM / 2008 / Intensive insulin therapy and pentastarch resuscitation in severe sepsis / N Engl J Med 358:125~139

Endo A / 2012 / Intraoperative hydroxyethyl starch 70/0.5 is not related to acute kidney injury in surgical patients: retrospective cohort study / Anesth Analg 115:1309~1314

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!