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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 233 - 243 (11page)
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Background: Hepatic steatosis is caused by metabolic stress associated with a positive lipid balance, such as insulin resistance and obesity. Previously we have shown the anti-obesity effects of inhibiting serotonin synthesis, which eventually improved insulin sensitivity and hepatic steatosis. However, it is not clear whether serotonin has direct effect on hepatic lipid accumulation. Here, we showed the possibility of direct action of serotonin on hepatic steatosis. Methods: Mice were treated with para-chlorophenylalanine (PCPA) or LP-533401 to inhibit serotonin synthesis and fed with high fat diet (HFD) or high carbohydrate diet (HCD) to induce hepatic steatosis. Hepatic triglyceride content and gene expression profiles were analyzed. Results: Pharmacological and genetic inhibition of serotonin synthesis reduced HFD-induced hepatic lipid accumulation. Furthermore, short-term PCPA treatment prevented HCD-induced hepatic steatosis without affecting glucose tolerance and browning of subcutaneous adipose tissue. Gene expression analysis revealed that the expressions of genes involved in de novo lipogenesis and triacylglycerol synthesis were downregulated by short-term PCPA treatment as well as long-term PCPA treatment. Conclusion: Short-term inhibition of serotonin synthesis prevented hepatic lipid accumulation without affecting systemic insulin sensitivity and energy expenditure, suggesting the direct steatogenic effect of serotonin in liver.
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참고문헌 (33)
참고문헌 신청
Farrell GC / 2006 / Nonalcoholic fatty liver disease: from steatosis to cirrhosis / Hepatology 43(2 Suppl 1):S99~S112
Baffy G / 2012 / Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace / J Hepatol 56:1384~1391
Adams LA / 2009 / NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study / Am J Gastroenterol 104:861~867
Kawano Y / 2013 / Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease / J Gastroenterol 48:434~441
Tchernof A / 2013 / Pathophysiology of human visceral obesity: an update / Physiol Rev 93:359~404
Baffy G / 2012 / Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace / J Hepatol 56:1384~1391
Adams LA / 2009 / NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study / Am J Gastroenterol 104:861~867
Kawano Y / 2013 / Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease / J Gastroenterol 48:434~441
Tchernof A / 2013 / Pathophysiology of human visceral obesity: an update / Physiol Rev 93:359~404
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