지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 207 - 214 (8page)
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초록· 키워드
오류제보하기
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor. PCSK9 has emerged as a target for lipid-lowering therapy, but the predictive value of the serum level of PCSK9 for the severity of coronary disease is largely unknown. Methods: From December 2009 to July 2012, 121 individuals who underwent coronary angiography (CAG) because of clinically suspected acute coronary syndrome were enrolled in this study. Serum levels of PCSK9 and metabolic parameters were measured. SYNTAX (SYNergy between percutaneous coronary intervention with [paclitaxel-eluting] TAXUS stent and cardiac surgery) and GRACE (Global Registry of Acute Coronary Events) scores were calculated. Results: Individuals with CAG lesions (n=100) had significantly higher levels of PCSK9 than those without lesions (n=21). The study population was stratified into three groups according to serum levels of PCSK9. The odds radio for occurrence of one or more CAG lesions was significantly higher in the group with the highest level of PCSK9 (odds ratio, 7.468; P=0.011) than in the group with the lowest level of PCSK9. Serum PCSK9 was positively associated with the number of involved coronary arteries. Multivariable linear regression indicated that levels of PCSK9 were positively correlated with GRACE risk scores and SYNTAX scores. Conclusion: Serum PCSK9 concentrations are higher in patients with coronary artery lesions, and are associated with SYNTAX and GRACE scores, suggesting that PCSK9 is a potential biomarker of the severity of coronary artery disease.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
del Val Martin D / 2015 / Biomarkers in acute coronary syndrome / IJC Metab Endocr 8:20~23
Ding Z / 2016 / Cross-talk between PCSK9 and damaged mtDNA in vascular smooth muscle cells: role in apoptosis / Antioxid Redox Signal 25:997~1008
Navarese EP / 2016 / Proprotein convertase subtilisin/kexin type 9 monoclonal antibodies for acute coronary syndrome: a narrative review / Ann Intern Med 164:600~607
Leander K / 2016 / Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) predicts future risk of cardiovascular events independently of established risk factors / Circulation 133:1230~1239
Gencer B / 2016 / Prognostic value of PCSK9 levels in patients with acute coronary syndromes / Eur Heart J 37:546~553
Ding Z / 2016 / Cross-talk between PCSK9 and damaged mtDNA in vascular smooth muscle cells: role in apoptosis / Antioxid Redox Signal 25:997~1008
Navarese EP / 2016 / Proprotein convertase subtilisin/kexin type 9 monoclonal antibodies for acute coronary syndrome: a narrative review / Ann Intern Med 164:600~607
Leander K / 2016 / Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) predicts future risk of cardiovascular events independently of established risk factors / Circulation 133:1230~1239
Gencer B / 2016 / Prognostic value of PCSK9 levels in patients with acute coronary syndromes / Eur Heart J 37:546~553
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