지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 257 - 264 (8page)
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Background: Insulin resistance is associated with the higher content of intermuscular adipose tissue (IMAT) and the saturation of intramyocellular lipid (IMCL), but a paucity of data exist in humans. This study examined associations among IMAT content, IMCL saturation, and fasting glucose concentration in middle-aged and older adults with overweight or obesity. Methods: Seventy-five subjects (26 males, 49 females) were recruited and thigh muscle and IMAT were assessed using magnetic resonance imaging. Vastus lateralis tissue was acquired from a subset of nine subjects and IMCL content and saturation were assessed using nonlinear dual complex microscopy. Results: The characteristics of the 75 subjects were as follows: age 59±11 years, body mass index 30±5 kg/m2, fasting glucose concentration 5.2±0.5 mmol/L, fasting insulin concentration 12.2±7.3 μU/mL, fasting homeostatic model assessment of insulin resistance (HOMA-IR) 2.9±2.0 (mean±SD). IMAT to muscle tissue (MT) volume ratio was positively associated with the saturated fatty acid to unsaturated fatty acid ratio in IMCL. IMAT:MT was positively associated with fasting glucose concentration and HOMA-IR. IMCL saturation was positively associated with fasting glucose concentration while muscle cell area, IMCL area, and % IMCL in muscle cell were not associated with fasting glucose concentration. Conclusion: These results indicate that higher intermuscular fat content and IMCL saturation may impact fasting glucose concentration in middle-aged and older adults with overweight or obesity. The centralization of adipose tissue in the appendicular region of the body may promote insulin resistance.
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참고문헌 (40)
참고문헌 신청
Trombetti A / 2016 / Age-associated declines in muscle mass, strength, power, and physical performance: impact on fear of falling and quality of life / Osteoporos Int 27:463~471
Ogden CL / 2014 / Prevalence of childhood and adult obesity in the United States, 2011-2012 / JAMA 311:806~814
Bjorntorp P / 1988 / Abdominal obesity and the development of noninsulin-dependent diabetes mellitus / Diabetes Metab Rev 4:615~622
Coen PM / 2012 / Role of intramyocelluar lipids in human health / Trends Endocrinol Metab 23:391~398
Goodpaster BH / 2000 / Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus / Am J Clin Nutr 71:885~892
Ogden CL / 2014 / Prevalence of childhood and adult obesity in the United States, 2011-2012 / JAMA 311:806~814
Bjorntorp P / 1988 / Abdominal obesity and the development of noninsulin-dependent diabetes mellitus / Diabetes Metab Rev 4:615~622
Coen PM / 2012 / Role of intramyocelluar lipids in human health / Trends Endocrinol Metab 23:391~398
Goodpaster BH / 2000 / Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus / Am J Clin Nutr 71:885~892
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