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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Osteolytic metastasis is a common destructive form of metastasis, in which there is an increased bone resorption but impaired bone formation. It is hypothesized that the changed mechanical properties of tumor affected bone cells could inhibit its mechanosensing, thus contributing to differences in bone remodeling. Methods: Here, atomic force microscopy indentation on primary bone cells exposed to 50% conditioned medium from Walker 256 (W) carcinoma cell line or its adaptive tumor (T) cells was carried out. Nitric oxide levels of bone cells were monitored in response to low-magnitude, high- frequency (LMHF) vibrations. Results: A stronger sustained inhibitive effect on bone cell viability and differentiation by T cells as compared to that of its cell line was demonstrated. This could be attributed to the higher levels of transforming growth factor-β1 (TGF-β1) in the T-conditioned medium as compared to W-conditioned medium. Bone cell elastic moduli in W and T-groups were found to decrease significantly by 61.0% and 69.6%, respectively compared to control and corresponded to filamentous actin changes. Nitric oxide responses were significantly inhibited in T-conditioned group but not in W-conditioned group. Conclusions: It implied that a change in cell mechanical properties is not sufficient as an indicator of change in mechanosensing ability. Moreover, inhibition of phosphoinositide 3-kinase/Akt downstream signaling pathway of TGF-β1 alleviated the inhibition effects on mechanosensing in T-conditioned cells, further suggesting that growth factors such as TGF-β could be good therapeutic targets for osteoblast treatment.
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참고문헌 (49)
참고문헌 신청
Bussard KM / 2009 / Ex-vivo analysis of the bone microenvironment in bone metastatic breast cancer / J Mammary Gland Biol Neoplasia 14:387~395
Kakonen SM / 2003 / Mechanisms of osteolytic bone metastases in breast carcinoma / Cancer 97:834~839
Kozlow W / 2005 / Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy / J Mammary Gland Biol Neoplasia 10:169~180
Phadke PA / 2006 / Kinetics of metastatic breast cancer cell trafficking in bone / Clin Cancer Res 12:1431~1440
Sasaki A / 1995 / Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice / Cancer Res 55:3551~3557
Kakonen SM / 2003 / Mechanisms of osteolytic bone metastases in breast carcinoma / Cancer 97:834~839
Kozlow W / 2005 / Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy / J Mammary Gland Biol Neoplasia 10:169~180
Phadke PA / 2006 / Kinetics of metastatic breast cancer cell trafficking in bone / Clin Cancer Res 12:1431~1440
Sasaki A / 1995 / Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice / Cancer Res 55:3551~3557
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