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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 999 - 1,004 (6page)
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Euphorbia humifusa Willd is an annual plant widely used as a vegetable and traditional medicinal herb. E. humifusa Willd displays a variety of pharmacological actions; however, the effect of E. humifusa Willd on the innate immune response has not been well characterized. The aim of this study is to investigate the effect of an E. humifusa Willd methanolic extract (EuH) on the activation of innate immune cells. Here, we found that the EuH increased the expression of the innate cytokines, TNFa and IL-1b, in THP-1 monocytes and THP-1-derived macrophages. In addition, the EuH enhanced the phagocytosis of THP-1-derived macrophages. These findings suggest that E. humifusa Willd may be helpful for preventing bacterial infection and could be developed as a dietary supplement for ameliorating innate immune response.
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참고문헌 (19)
참고문헌 신청
Cohen P / 2014 / The TLR and IL-1 signalling network at a glance / J Cell Sci 127:2383~2390
Deng F / 2008 / New alphapyrrolidinonoids and glycosides from Euphorbia humifusa / J Asian Nat Prod Res 10:531~539
Gordon S / 2005 / Monocyte and macrophage heterogeneity / Nat Rev Immunol 5:953~964
Hoffmann JA / 1999 / Phylogenetic perspectives in innate immunity / Science 284:1313~1318
Kitchens RL / 2000 / Role of CD14 in cellular recognition of bacterial lipopolysaccharides / Chem Immunol 74:61~82
Deng F / 2008 / New alphapyrrolidinonoids and glycosides from Euphorbia humifusa / J Asian Nat Prod Res 10:531~539
Gordon S / 2005 / Monocyte and macrophage heterogeneity / Nat Rev Immunol 5:953~964
Hoffmann JA / 1999 / Phylogenetic perspectives in innate immunity / Science 284:1313~1318
Kitchens RL / 2000 / Role of CD14 in cellular recognition of bacterial lipopolysaccharides / Chem Immunol 74:61~82
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