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논문 기본 정보

자료유형
학술저널
저자정보
Xiaoliu Dong (Tangshan People’s Hospital) Tiejun Liu (North China University of Science and Technology Affiliated Hospital) Shijun Xu (Tangshan People’s Hospital) Lixia Zhu (Tangshan People’s Hospital) Panpan Zhang (North China University of Science and Technology Affiliated Hospital) Aibin Cheng (North China University of Science and Technology Affiliated Hospital) Qingqiang Qian (North China University of Science and Technology Affiliated Hospital)
저널정보
한국유전학회 Genes & Genomics Genes & Genomics Vol.38 No.3
발행연도
2016.1
수록면
243 - 250 (8page)

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To investigate the relevance of ABCA1 R219K polymorphisms and serum ABCA1 protein concentration to Parkinson’s disease (PD) pathogenesis and classification in Chinese population. Between June 2013 to January 2014, 108 patients diagnosed with PD at Department of Neurology, Tangshan People’s Hospital, Tangshan were enrolled in the PD group, and 123 healthy individuals, from Health Screening Center of the same hospital, with matched age, gender, and education were enrolled in the control group. Polymerase chain reaction–restriction fragment length polymorphism method was used to detect ABCA1 R219K polymorphisms and enzyme-linked immunosorbent assay used to measure serum ABCA1 concentrations. Frequencies of R/K and K/K genotypes, and K allele of ABCA1 R219K polymorphisms were significantly lower in the PD group than the control group (all P\0.05). Significant differences existed in distributions of genotype frequencies, including R/R, R/K and K/K, between PD and control group of each classification (all P\0.05). ABCA1 concentrations were significantly different in the PD and control group (P\0.05); also ABCA1 concentrations were very different among PD patients with different genotypes (all P\0.05). Serum concentrations of ABCA1were significantly different among PD patients in different classifications (all P\0.05), suggesting the negative correlation between ABCA1 serum concentration and PD classification (r = -0.776, P\0.05). And serum concentrations of ABCA1 showed obvious differences among cases with three different genotypes in each classification (all P\0.05). ABCA1 R219K polymorphisms and serum concentration were associated with pathogenesis and classification of PD, and K allele may be a protective genetic factor.

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참고문헌 (29)

참고문헌 신청
Chen Y / 2014 / Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma / Nat Genet 46:1115~1119 google schola Choi HY / 2003 / Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human Niemann- Pick type C disease / J Biol Chem 278:32569~32577 google schola Collins LM / 2012 / Contributions of central and systemic inflammation to the pathophysiology of Parkinson’s disease / Neuropharmacology 62:2154~2168 google schola Corti O / 2011 / What genetics tells us about the causes and mechanisms of Parkinson’s disease / Physiol Rev 91:1161~1218 google schola Emre M / 2007 / Clinical diagnostic criteria for dementia associated with Parkinson’s disease / Mov Disord 22:1689~1707 google schola

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