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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Programmed death 1 (PD-1) is a coinhibitory receptor on the T-cell surface and its primary biological function is to maintain peripheral tolerance by suppressing T-cell activation through the interaction with its ligands PD-L1 and PD-L2. However, cancer cells can evade immunological recognition and destruction by activating coinhibitory pathways through the molecular interactions of PD-1. Recently, the FDA-approved antibodies targeting PD-1 have brought about a significant breakthrough in the treatment of a wide range of cancers, as they can induce durable therapeutic responses. Here, the Fab fragment of camrelizumab, a therapeutic antibody against PD-1, was overexpressed in the periplasmic region of Escherichia coli and purified, and crystallized. The crystal diffracted to 3.25 Å resolution and belonged to the space group C2, with unit cell parameters a = 274.24, b = 77.90, c = 97.16 Å, and β = 101.93˚. An asymmetric unit of the crystal contains four molecules of the Fab fragment of camrelizumab with a VM of 2.51 Å3 Da-1 and a solvent content of 50.96%.
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참고문헌 (17)
참고문헌 신청
Adams, P. D. / 2010 / PHENIX : a comprehensive Python-based system for macromolecular structure solution / Acta Crystallogr D Biol Crystallogr d66:213~221
Emsley, P. / 2004 / Coot : model-builiding tools for molecular graphics / Acta Crystallogr D Biol Crystallogr 60:2126~2132
Garon, E. B. / 2015 / Pembrolizumab for the treatment of non-small-cell lung cancer / N Engl J Med 372:2018~2028
Hamid, O. / 2013 / Safety and tumor responses with lambrolizumab(anti-PD-1)in melanoma / N Engl J Med 369:134~144
Iwai, Y. / 2017 / Cancer immunotherapies targeting the PD-1 signaling pathway / J Biomed Sci 24:26
Emsley, P. / 2004 / Coot : model-builiding tools for molecular graphics / Acta Crystallogr D Biol Crystallogr 60:2126~2132
Garon, E. B. / 2015 / Pembrolizumab for the treatment of non-small-cell lung cancer / N Engl J Med 372:2018~2028
Hamid, O. / 2013 / Safety and tumor responses with lambrolizumab(anti-PD-1)in melanoma / N Engl J Med 369:134~144
Iwai, Y. / 2017 / Cancer immunotherapies targeting the PD-1 signaling pathway / J Biomed Sci 24:26
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