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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 127 - 135 (9page)
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The metallothionein 2 (mt2) genomic gene with 667 bp was cloned from the grass carp (Ctenopharyngodon idellus). The structure of mt2 gene was similar with the reported vertebrae mt gene, containing three exons interrupted by two introns. Only one MRE mortify was found in the 50 flanking region at proximal cluster which was quite different from the previous reports. The number of deduced amino acid was 60, characterized by cysteine-rich. The basal levels and the transcriptional responses of mt2 gene in different organs to cadmium (Cd) were measured using the quantitative real-time PCR (qRT-PCR). In the kidney, the constructive level of the mt2 mRNA was the highest, while the lowest expression level was detected in the skin. The induced impacts of Cd on mt2 mRNA expression were various from tissues. In the liver, gill and skin, the gene was quickly induced at 6 h. After a transient suppression, the expression levels of mt2 mRNA were increased in the intestine and spleen at 12 h, and mt2 mRNA expressed upwards in the bone at 24 h. In the kidney and bone, the expressions elevated only after 48 h Cd induction. The inducibility of mt2 gene to Cd demonstrated that it played a significant role during the metal toxicant detoxification in grass carp and the mt2 gene in the liver was most sensitive to Cd induction.
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참고문헌 (39)
참고문헌 신청
Arini A / 2015 / Metal detoxification and gene expression regulation after a Cd and Zn contamination: an experimental study on Danio rerio / Chemosphere 128:125~133
Basha PS / 2003 / Cadmium-induced antioxidant defense mechanism in freshwater teleost Oreochromis mossambicus (Tilapia) / Ecotoxicol Environ Saf 56:218~221
Bourdineaud JP / 2006 / Challenging the model for induction of metallothionein gene expression / Biochimie 88:1787~1792
Brugnera E / 1994 / Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1 / Nucleic Acids Res 22:3167~3173
Burger J / 2009 / Comparison of arsenic, cadmium, chromium, lead, manganese, mercury and selenium in feathers in bald eagle (Haliaeetus leucocephalus), and comparison with common eider (Somateria mollissima), glaucous-winged gull (Larus glaucescens), pigeon guillemot (Cepphus columba), and tufted puffin (Fratercula cirrhata) from the Aleutian Chain of Alaska / Environ Monit Assess 152:357~367
Basha PS / 2003 / Cadmium-induced antioxidant defense mechanism in freshwater teleost Oreochromis mossambicus (Tilapia) / Ecotoxicol Environ Saf 56:218~221
Bourdineaud JP / 2006 / Challenging the model for induction of metallothionein gene expression / Biochimie 88:1787~1792
Brugnera E / 1994 / Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1 / Nucleic Acids Res 22:3167~3173
Burger J / 2009 / Comparison of arsenic, cadmium, chromium, lead, manganese, mercury and selenium in feathers in bald eagle (Haliaeetus leucocephalus), and comparison with common eider (Somateria mollissima), glaucous-winged gull (Larus glaucescens), pigeon guillemot (Cepphus columba), and tufted puffin (Fratercula cirrhata) from the Aleutian Chain of Alaska / Environ Monit Assess 152:357~367
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