지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,468 - 1,473 (6page)
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초록· 키워드
오류제보하기
Several clinical studies have proposed a protective role for vitamin E (α-tocopherol) against contrast-induced acute kidney injury (CIAKI). The aim of study was to assess the effects of vitamin E for the prevention of CIAKI. A systematic review and meta-analysis was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials. Randomized controlled trials (RCTs) reporting the effects of vitamin E on CIAKI development and measurements of renal function were included. Four trials including 623 participants were analyzed in the meta-analysis. All participants received intravenous hydration in addition to vitamin E or placebo. The incidence of the vitamin E group (5.8%) was lower than that of the control group (15.4%). Compared with the control, vitamin E significantly reduced the risk ratio (RR) of CIAKI by 62% (0.38; 95% confidence interval [CI], 0.22, 0.63; P < 0.010). In addition, vitamin E reduced serum creatinine (SCr) increase after contrast administration (standardized mean difference [SMD], −0.27; 95% CI, −0.49, −0.06; P = 0.010). However, changes in glomerular filtration rate (GFR) after contrast administration were not significantly different between vitamin E and the control group (SMD, 0.21; 95% CI, −0.01, 0.43; P = 0.060). Heterogeneity within the available trials was not observed. Our meta-analysis provides evidence that vitamin E plus hydration significantly reduced the risk of CIAKI in patients with renal impairment compared with hydration alone.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Tepel M / 2006 / Contrast-induced nephropathy : a clinical and evidence-based approach / Circulation 113:1799~1806
Sadat U / 2013 / Does ascorbic acid protect against contrast-induced acute kidney injury in patients undergoing coronary angiography: a systematic review with meta-analysis of randomized, controlled trials / J Am Coll Cardiol 62:2167~2175
Morcos SK / 1999 / Contrast-media-induced nephrotoxicity: a consensus report. Contrast media safety committee, European society of urogenital radiology (ESUR) / Eur Radiol 9:1602~1613
Manske CL / 1990 / Contrast nephropathy in azotemic diabetic patients undergoing coronary angiography / Am J Med 89:615~620
Parfrey PS / 1989 / Contrast material-induced renal failure in patients with diabetes mellitus, renal insufficiency, or both. A prospective controlled study / N Engl J Med 320:143~149
Sadat U / 2013 / Does ascorbic acid protect against contrast-induced acute kidney injury in patients undergoing coronary angiography: a systematic review with meta-analysis of randomized, controlled trials / J Am Coll Cardiol 62:2167~2175
Morcos SK / 1999 / Contrast-media-induced nephrotoxicity: a consensus report. Contrast media safety committee, European society of urogenital radiology (ESUR) / Eur Radiol 9:1602~1613
Manske CL / 1990 / Contrast nephropathy in azotemic diabetic patients undergoing coronary angiography / Am J Med 89:615~620
Parfrey PS / 1989 / Contrast material-induced renal failure in patients with diabetes mellitus, renal insufficiency, or both. A prospective controlled study / N Engl J Med 320:143~149
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