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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 942 - 947 (6page)
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초록· 키워드
오류제보하기
Oral anticoagulant therapy is frequently and increasingly prescribed for patients at risk of arterial or venous thromboembolism (VTE). Although elective surgical or invasive procedures have necessitated temporary interruption of anticoagulants, managing these patients has been performed empirically and been poorly investigated. This study was designed to evaluate the adequacy of perioperative anticoagulation using enoxaparin. This was a retrospective, single-center study that evaluated the efficacy and safety of therapeutic-dose enoxaparin for bridging therapy in patients on long-term warfarin at Soonchunhyang University Hospital in Korea between August 2009 and July 2011. Warfarin was discontinued 5 days before surgery, and enoxaparin was administered twice daily by subcutaneous injection at a dose of 1 mg per kg from 3 days before the procedure to the last dose 24 hours before the procedure. Anticoagulation was restarted if proper hemostasis had been confirmed. There were 49 patients, of whom 25 (51%) were men, and the mean age was 63 years. Thirty-four (69%) received warfarin therapy for VTE, and 9 (18%) for atrial fibrillation. Twenty-nine patients (59%) underwent major surgery and 20 (41%) minor surgery. The mean postoperative duration of enoxaparin was 4 days. No patients had thromboembolic complications through 30 days after the procedure. The overall 30-day mortality rate was 0%. In conclusion, our findings demonstrate that bridging therapy with therapeutic-dose enoxaparin is feasible and associated with a low incidence of major bleeding and no thromboembolic complications. However, the optimal approach to managing patients perioperatively is uncertain and requires further evaluation.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Singer DE / 2004 / Antithrombotic therapy in atrial fibrillation : the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy / Chest 126:429~456
Dunn AS / 2003 / Perioperative management of patients receiving oral anticoagulants : a systematic review / Arch Intern Med 163:901~908
Tiede DJ / 1998 / Modern management of prosthetic valve anticoagulation / Mayo Clin Proc 73:665~680
Longstreth WT Jr / 2001 / Frequency and predictors of stroke death in 5,888 participants in the Cardiovascular Health Study / Neurology 56:368~375
Spyropoulos AC / 2006 / Clinical outcomes with unfractionated heparin or low-molecular-weight heparin as bridging therapy in patients on long-term oral anticoagulants : the REGIMEN registry / J Thromb Haemost 4:1246~1252
Dunn AS / 2003 / Perioperative management of patients receiving oral anticoagulants : a systematic review / Arch Intern Med 163:901~908
Tiede DJ / 1998 / Modern management of prosthetic valve anticoagulation / Mayo Clin Proc 73:665~680
Longstreth WT Jr / 2001 / Frequency and predictors of stroke death in 5,888 participants in the Cardiovascular Health Study / Neurology 56:368~375
Spyropoulos AC / 2006 / Clinical outcomes with unfractionated heparin or low-molecular-weight heparin as bridging therapy in patients on long-term oral anticoagulants : the REGIMEN registry / J Thromb Haemost 4:1246~1252
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