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논문 기본 정보

자료유형
학술저널
저자정보
박동원 (한양대학교) Moritoki Egi (Kobe University Hospital) Masaji Nishimura (Tokushima University Hospital) 장유진 (충북대학교) 서기영 (성균관대학교) 임채만 (울산대학교) 김재열 (중앙대학교) Keiichi Tada (Hiroshima City Hospital) Koichi Matsuo (New Tokyo Hospital) Shinhiro Takeda (Nippon Medical School Hospital) Ryosuke Tsuruta (Yamaguchi University Hospital) Takeshi Yokoyama (Teine Keijinkai Hospital) 김선옥 (울산대학교) 고윤석 (울산대학교)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.31 No.12
발행연도
2016.1
수록면
2,033 - 2,041 (9page)

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This research aims to investigate the impact of fever on total mechanical ventilation time (TVT) in critically ill patients. Subgroup analysis was conducted using a previous prospective, multicenter observational study. We included mechanically ventilated patients for more than 24 hours from 10 Korean and 15 Japanese intensive care units (ICU), and recorded maximal body temperature under the support of mechanical ventilation (MAXMV). To assess the independent association of MAXMV with TVT, we used propensity-matched analysis in a total of 769 survived patients with medical or surgical admission, separately. Together with multiple linear regression analysis to evaluate the association between the severity of fever and TVT, the effect of MAXMV on ventilator-free days was also observed by quantile regression analysis in all subjects including non-survivors. After propensity score matching, a MAXMV ≥ 37.5°C was significantly associated with longer mean TVT by 5.4 days in medical admission, and by 1.2 days in surgical admission, compared to those with MAXMV of 36.5°C to 37.4°C. In multivariate linear regression analysis, patients with three categories of fever (MAXMV of 37.5°C to 38.4°C, 38.5°C to 39.4°C, and ≥ 39.5°C) sustained a significantly longer duration of TVT than those with normal range of MAXMV in both categories of ICU admission. A significant association between MAXMV and mechanical ventilator-free days was also observed in all enrolled subjects. Fever may be a detrimental factor to prolong TVT in mechanically ventilated patients. These findings suggest that fever in mechanically ventilated patients might be associated with worse mechanical ventilation outcome.

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