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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 649 - 659 (11page)
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Nontuberculous mycobacteria (NTM) are ubiquitous organisms; their isolation from clinical specimens does not always indicate clinical disease. The incidence of NTM lung diseases has been increasing worldwide. Although the geographic diversity of NTM species is well known, Mycobacterium avium complex (MAC), M. abscessus complex (MABC), and M. kansasii are the most commonly encountered and important etiologic organisms. Two distinct types of NTM lung diseases have been reported, namely fibrocavitary and nodular bronchiectatic forms. For laboratory diagnosis of NTM lung diseases, both liquid and solid media cultures and species-level identification are strongly recommended to enhance growth detection and determine the clinical relevance of isolates. Treatment for NTM lung diseases consists of a multidrug regimen and a long course of therapy, lasting more than 12 months after negative sputum conversion. For MAC lung disease, several new macrolide-based regimens are now recommended. For nodular bronchiectatic forms of MAC lung diseases, an intermittent three-time-weekly regimen produces outcomes similar to those of daily therapy. Treatment of MABC lung disease is very difficult, requiring longterm use of parenteral agents in combination with new macrolides. Treatment outcomes are much better for M. massiliense lung disease than for M. abscessus lung disease. Thus, precise identification of species in MABC infection is needed for the prediction of antibiotic response. Likewise, increased efforts to improve treatment outcomes and develop new agents for NTM lung disease are needed.
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참고문헌 (100)
참고문헌 신청
Griffith DE / 2007 / An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases / Am J Respir Crit Care Med 175:367~416
Falkinham JO 3rd / 2015 / Environmental sources of nontuberculous mycobacteria / Clin Chest Med 36:35~41
Szymanski EP / 2015 / Pulmonary nontuberculous mycobacterial infection. A multisystem, multigenic disease / Am J Respir Crit Care Med 192:618~628
Adjemian J / 2012 / Spatial clusters of nontuberculous mycobacterial lung disease in the United States / Am J Respir Crit Care Med 186:553~558
Prevots DR / 2015 / Epidemiology of human pulmonary infection with nontuberculous mycobacteria : a review / Clin Chest Med 36:13~34
Falkinham JO 3rd / 2015 / Environmental sources of nontuberculous mycobacteria / Clin Chest Med 36:35~41
Szymanski EP / 2015 / Pulmonary nontuberculous mycobacterial infection. A multisystem, multigenic disease / Am J Respir Crit Care Med 192:618~628
Adjemian J / 2012 / Spatial clusters of nontuberculous mycobacterial lung disease in the United States / Am J Respir Crit Care Med 186:553~558
Prevots DR / 2015 / Epidemiology of human pulmonary infection with nontuberculous mycobacteria : a review / Clin Chest Med 36:13~34
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