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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.10 No.4
- 발행연도
- 2018.1
- 수록면
- 420 - 424 (5page)
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초록· 키워드
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The major apple allergen Mal d 1 cross-reacts with the homologous birch pollen allergen Bet v 1 and causes immunoglobulin E (IgE)-mediated immediate- type allergic reactions. In some patients, delayed-type hypersensitivity to apples may develop within 72 hours without evidence of specific IgE or a positive skin prick test (SPT). The aim of the study was to evaluate the concomitance of delayed-type hypersensitivity reactions and immediate IgE-mediated reactions against high- and low-allergenic apple cultivars in patients with birch pollen allergy. Data were obtained from 45 adults with clinical symptoms of birch pollen allergy. Patients were exposed to apple pulp via atopy patch tests (APTs) and SPTs. Levels of IgE specific to Bet v 1 and Mal d 1 were measured with a radioallergosorbent test. Patients allergic to birch pollen showed the highest rate of positive SPT responses to Golden Delicious apples and the lowest rate to low-allergenic cultivar Grey French Reinette. Among these patients, 9% developed delayed hypersensitivity reactions to either Golden Delicious or Grey French Reinette apples; these reactions manifested clinically as erythema with papules (class ++). Fifty percent of APT-positive patients were concomitantly SPT-negative. Here, we show for the first time the clinical relevance of T cell-driven allergic reactions to apples. APTs may reveal type IV sensitization in patients who are negative for the corresponding type I sensitization tests. Thus, utilization of the APT procedure with fresh apple appears to be a valuable tool for the diagnosis of apple allergy and may improve the accuracy of food allergy diagnoses.
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참고문헌 (27)
참고문헌 신청
Vegro M / 2016 / Old apple (Malus domestica L. Borkh) varieties with hypoallergenic properties: an integrated approach for studying apple allergenicity / J Agric Food Chem 64:9224~9236
Bohle B / 2006 / Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo / J Allergy Clin Immunol 118:242~249
Jahn-Schmid B / 2005 / Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens / J Allergy Clin Immunol 116:213~219
Wagner A / 2016 / Allergy to apple cultivars among patients with birch pollinosis and oral allergy syndrome / Ann Allergy Asthma Immunol 117:399~404
Smole U / 2008 / Mal d 2, the thaumatin-like allergen from apple, is highly resistant to gastrointestinal digestion and thermal processing / Int Arch Allergy Immunol 147:289~298
Bohle B / 2006 / Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo / J Allergy Clin Immunol 118:242~249
Jahn-Schmid B / 2005 / Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens / J Allergy Clin Immunol 116:213~219
Wagner A / 2016 / Allergy to apple cultivars among patients with birch pollinosis and oral allergy syndrome / Ann Allergy Asthma Immunol 117:399~404
Smole U / 2008 / Mal d 2, the thaumatin-like allergen from apple, is highly resistant to gastrointestinal digestion and thermal processing / Int Arch Allergy Immunol 147:289~298
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