지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 197 - 205 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Although microinvasive carcinoma is distinct from ductal carcinoma in situ (DCIS), the clinical significance of microinvasion in DCIS remains elusive. The purpose of this study is to evaluate the clinicopathological features and clinical outcomes of microinvasive carcinoma compared with pure DCIS. Methods: We assessed 613 cases of DCIS and microinvasive carcinoma that were consecutively resected from 2003 to 2014 and analyzed clinicopathological variables, expression of standard biomarkers such as the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), p53, and Ki-67, and tumor recurrence. Results: Among the 613 cases, 136 (22.2%) were classified as microinvasive carcinoma. Microinvasive carcinoma was significantly associated with DCIS with a large extent, high nuclear grade, necrosis, and comedotype architectural pattern. ER and PR expressions were dominantly observed in pure DCIS, whereas positive HER2 status, p53 overexpression, and high Ki-67 proliferation indices were more frequently observed in microinvasive carcinoma. Lymph node metastasis was found in only four cases of microinvasive carcinoma with multifocal microinvasion. In the multivariate analysis, DCIS with a large extent, comedo-type architectural pattern, and negative ER status were found to be independent predictors of microinvasion. During follow-up, 12 patients had ipsilateral breast recurrence, and no differences in recurrence rates were observed between patients with DCIS and those with microinvasive carcinoma. The triple-negative subtype was the only factor that was associated with tumor recurrence. Conclusion: Microinvasive carcinomas are distinct from DCIS in terms of clinicopathological features and biomarker expressions but are similar to DCIS in terms of clinical outcomes. Our results suggest that microinvasive carcinoma can be treated and followed up as pure DCIS.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66:7~30
Silver SA / 1998 / Mammary ductal carcinoma in situ with microinvasion / Cancer 82:2382~2390
Lagios MD / 1982 / Duct carcinoma in situ: relationship of extent of noninvasive disease to the frequency of occult invasion, multicentricity, lymph node metastases, and shortterm treatment failures / Cancer 50:1309~1314
Silverstein MJ / 1990 / Intraductal carcinoma of the breast (208 cases): clinical factors influencing treatment choice / Cancer 66:102~108
Royal College of Pathologists Working Group / 1991 / Pathology reporting in breast cancer screening / J Clin Pathol 44:710~725
Silver SA / 1998 / Mammary ductal carcinoma in situ with microinvasion / Cancer 82:2382~2390
Lagios MD / 1982 / Duct carcinoma in situ: relationship of extent of noninvasive disease to the frequency of occult invasion, multicentricity, lymph node metastases, and shortterm treatment failures / Cancer 50:1309~1314
Silverstein MJ / 1990 / Intraductal carcinoma of the breast (208 cases): clinical factors influencing treatment choice / Cancer 66:102~108
Royal College of Pathologists Working Group / 1991 / Pathology reporting in breast cancer screening / J Clin Pathol 44:710~725
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Clinicopathological markers associated with recurrence in ductal carcinoma in situ of breast by age group
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2018 .06
-
Predictors for the Transition from Ductal Carcinoma In Situ to Invasive Breast Cancer in Korean Patients
Journal of Breast Disease
2016 .06
-
Controversial Issues in the Treatment of DCIS
대한외과학회 학술대회 초록집
2017 .11
-
Increased mitochondrial dysfunction associated with autophagy and mitophagy in cerebrospinal fluid cells following SAH in patients with DCI
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Possible Prognostic Role of HER2/Neu in Ductal Carcinoma In Situ and Atypical Ductal Proliferative Lesions of the Breast
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Clinicopathologic Factors Of DCIS Patients Associated with Relapse
대한외과학회 학술대회 초록집
2018 .11
-
An Updated Nomogram for Predicting Invasiveness in Preoperative Ductal Carcinoma In Situ of the Breast
Yonsei Medical Journal
2019 .01
-
Ultrasound Breast Elastographic Evaluation of Mass-Forming Ductal Carcinoma-in-situ with Histological Correlation - New Findings for a Toothpaste Sign
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
The Impact of Androgen Receptor and Histone Deacetylase 1 Expression on the Prognosis of Ductal Carcinoma In Situ
Journal of Breast Cancer
2020 .01
-
Prognostic implications of ductal carcinoma in situ components in BRCA1/2-positive breast cancer: a retrospective cohort study
Annals of Surgical Treatment and Research
2024 .12
-
Does Microinvasive Adenocarcinoma of Cervix Have Poorer Treatment Outcomes than Microinvasive Squamous Cell Carcinoma?
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
초음파에서 고위험 병변과 DCIS
대한초음파의료영상학회 학술대회 초록집
2023 .05
-
Synchronous Presentation of Ductal Carcinoma In Situ of the Breast with Follicular Lymphoma
Journal of Breast Disease
2017 .12
-
Comparison of Ipsilateral Breast Tumor Recurrence Rate between Re-Excision and Radiotherapy Only Group When Surgical Margin Involvement of DCIS after Breast-Conserving Surgery
대한외과학회 학술대회 초록집
2021 .05
-
유방 관상피내암에서 초음파와 MRI의 종양 크기 예측 정확도 비교
Journal of Breast Disease
2021 .12
-
Inhibitory Effect of D-chiro-inositol on Both Growth and Recurrence of Breast Tumor from MDA-MB-231 Cancer Cells
Natural Product Sciences
2017 .03
-
Survival Outcomes Based on Axillary Surgery in Ductal Carcinoma In Situ : A Nationwide Study From the Korean Breast Cancer Society
Journal of Breast Cancer
2024 .02
-
Pathologic differential diagnosis of metastatic carcinoma in the liver
Clinical and Molecular Hepatology
2019 .01
-
Clinical Characteristics and Prognosis of Metaplastic Carcinoma of the Breast Compared with Invasive Ductal Carcinoma: A Propensity-Matched Analysis
대한외과학회 학술대회 초록집
2021 .11
-
A combined large-cell neuroendocrine carcinoma and hepatocellular carcinoma tumor in the liver: A rare case report
Annals of Hepato-Biliary-Pancreatic Surgery
2022 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0