메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
이충만 (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) 정일용 (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College of) 박양순 (Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) 윤경원 (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College of) 조휘경 (Biomedical Science Department of Biomedical Science Asan Medical Center Seoul Korea) 박혜진 (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College of) 이희진 (Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) 이새별 (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College of) 김희정 (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College of) 고범석 (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College of) 이종원 (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College) 손병호 (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College of) 안세현 (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College of) 김지선 (Division of Breast Surgery Department of Surgery Asan Medical Center University of Ulsan College of)
저널정보
한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.23 No.6
발행연도
2020.1
수록면
610 - 621 (12page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Purpose: Factors associated with invasive recurrence (REC) of ductal carcinoma in situ (DCIS) are less known. This study was aimed at identifying better biomarkers to predict the prognosis of DCIS. Methods: RNA extracted from formalin-fixed paraffin-embedded blocks of twenty-four pure DCIS cases was subjected to differential gene expression analysis. The DCIS cases were selected by matching age and estrogen receptor status. Sixteen REC-free and 8 invasive-REC cases with disease-free interval of > 5 years were analyzed. Immunohistochemistry (IHC) staining was used to validate sixty-one independent pure DCIS cases, including invasive-REC (n = 16) and REC-free (n = 45) cases. Results: Eight differentially expressed genes (DEGs) were statistically significant (log 2-fold change [FC] < –1 or > 1 and p < 0.001). Less than ½ fold expression of CUL1, androgen receptor (AR), RPS27A, CTNNB1, MAP3K1, PRKACA, GNG12, MGMT genes was observed in the REC group compared to the no evidence of disease group. AR and histone deacetylase 1 (HDAC1) genes were selected for external validation (AR: log 2-FC − 1.35, p < 0.001, and HDAC1: log 2-FC − 0.774, p < 0.001). External validation showed that the absence of AR and high HDAC1 expression were independent risk factors for invasive REC (hazard ratio [HR], 5.04; 95% confidence interval [CI], 1.24–20.4; p = 0.023 and HR, 3.07; 95% CI, 1.04–9.04; p = 0.042). High nuclear grade 3 was also associated with long-term invasive REC. Conclusion: Comparative gene expression analysis of pure DCIS revealed 8 DEGs among recurring cases. External validation with IHC suggested that the absence of AR and overexpression of HDAC1 are associated with a greater risk of long-term invasive REC of pure DCIS.
#Receptors #androgen #Carcinoma #intraductal #noninfiltrating #Histone deacetylase 1 #Prognosis

목차

등록된 정보가 없습니다.

참고문헌 (29)

참고문헌 신청
Early Breast Cancer Trialists' Collaborative Group(EBCTCG) / 2010 / Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast / J Natl Cancer Inst Monogr 2010:162~177 google schola McCormick B / 2015 / RTOG 9804 : a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation / J Clin Oncol 33:709~715 google schola Solin LJ / 2015 / Surgical excision without radiation for ductal carcinoma in situ of the breast : 12-year results from the ECOG-ACRIN E5194 study / J Clin Oncol 33:3938~3944 google schola Wong JS / 2014 / Eight-year update of a prospective study of wide excision alone for small low-or intermediate-grade ductal carcinoma in situ(DCIS) / Breast Cancer Res Treat 143:343~350 google schola Gilleard O / 2008 / The significance of the Van Nuys prognostic index in the management of ductal carcinoma in situ / World J Surg Oncol 6:61 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0