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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 170 - 173 (4page)
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초록· 키워드
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Objectives: The calcemic and parathyroid hormone (PTH) responses to severe burn injury appear to differ between children and adults. In our limited studies children exhibited hypocalcemic hypoparathyroidism consistent with up-regulation of the parathyroid calcium-sensing receptor (CaSR) while adults did not, suggesting a developmental cutoff in cytokine-mediated up-regulation of the CaSR. This difference may be clinically important as published studies indicate that extracellular calcium (Ca) may stimulate the inflammatory response. The aim of this study was to examine the existing literature on burns to see if the differences between pediatric and adult calcemic and PTH responses to burn supported our findings providing stronger evidence to support this developmental difference. Methods: We reviewed the National Library of Medicine database using the terms burns, PTH and ionized calcium and found 9 articles from 8 different medical centers; one was eliminated due to mixing of adults and children. Results: There were 245 burn patients reported from the literature, 178 pediatric and 67 adults. The data are mostly consistent with our reported findings. Of the 10 pediatric patients with severe burns that we studied, mean ionized Ca concentration was below the lower limit of normal of 1.10 mM. The 67 adult burn patients reported in the literature had a mean blood ionized Ca concentration that was within the adult normal range or was lower than normal but with secondary hyperparathyroidism. Moreover, serum PTH concentrations were uniformly low in the 178 children in the burn literature but normal or mildly elevated in the 67 adults. Conclusions: These results support the hypothesis that the difference between pediatric and adult victims is consistent with an age-related CaSR response to cytokine stimulation and may be consistent with a lower level of inflammation in children. Ionized Ca and PTH might serve as possible therapeutic targets to lower the inflammatory response in burn victims. © 2017 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Klein GL / 2014 / Preliminary evidence of early bone resorption in a sheep model of acute burn injury: an observational study / J Bone Miner Metab 32:136~141
Klein GL / 1995 / Histomorphometric and biochemical characterization of bone following acute severe burns in children / Bone 17:455~460
Klein GL / 2004 / Evidence supporting a role of glucocorticoids in short-term bone loss in burned children / Osteoporos Int 15:468~474
Klein GL / 1997 / Dysregulation of calcium homeostasis after severe burn injury in children: possible role of magnesium depletion / J Pediatr 131:246~251
Murphey ED / 2000 / Upregulation of the parathyroid calcium-sensing receptor after burn injury in sheep: a potential contributory factor to postburn hypocalcemia / Crit Care Med 28:3885~3890
Klein GL / 1995 / Histomorphometric and biochemical characterization of bone following acute severe burns in children / Bone 17:455~460
Klein GL / 2004 / Evidence supporting a role of glucocorticoids in short-term bone loss in burned children / Osteoporos Int 15:468~474
Klein GL / 1997 / Dysregulation of calcium homeostasis after severe burn injury in children: possible role of magnesium depletion / J Pediatr 131:246~251
Murphey ED / 2000 / Upregulation of the parathyroid calcium-sensing receptor after burn injury in sheep: a potential contributory factor to postburn hypocalcemia / Crit Care Med 28:3885~3890
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